Correlation Analysis Of Peripheral Venous Blood Lipoprotein A,Nitric Oxide, Malondialdehyde And Erectile Dysfunction In Diabetes

[Background]:Erectile dysfunction (Erectile dysfunction, ED) is a kind of common and frequently-occurring disease in the world, about150000000men with some degree of erectile dysfunction, and erectile dysfunction in patients with diabetes is one of the most common complications. With China’s continuous improvement of people’s living standard, the incidence of diabetes was an upward trend year after year, to2010, worldwide diabetes will reach2a hundred million diabetic patients is about20000000～40000000In China,. People with diabetes mellitus cardiovascular, renal, retinal complications such as the study of earlier and achieved certain results, and patients with diabetes mellitus complicated with erectile dysfunction is only in recent years have been pay more attention, and the pathogenesis is still not clear. Therefore, for its etiology and mechanism can provide theoretical bases for clinical treatment and guidance.[Objective]To observe diabetic erectile dysfunction in patients with peripheral venous blood lipoprotein a, nitric oxide, malondialdehyde levels, and discussed the relationship between diabetic erectile dysfunction and its clinical application value for diabetic erectile dysfunction, clinical diagnosis and treatment theoretical basis.[Methods] In our hospital endocrine division for treatment of type2diabetic patients complicated with ED in31cases as the case group of patients in2008the object and method of October to2010November, all cases patients are consistent with:in1999WHO diagnostic criteria of diabetes, and insulin release test type diagnosed as type2diabetes, and according to the United States National Institute of Health Institute consensus panel (Nationallnstitutes of Health, NIH) to develop the international index of erectile function (IIEF-5) diagnostic criteria for the diagnosis of ED patients, and the detection of the sex hormone5and with the exception of other endocrine diseases caused by ED, and all patients were not hypertensive disease, spinal cord injury, penile lesions, and mental disorders and pudendal injuries, operation or other can result in ED disease. A case group of patients aged48to52years, mean42.37+6.8years of age, diabetes duration of3to10years, the average duration of4.2+4.6years, international index of erectile function (IIEF-5) score:11～8in11cases;7is divided into the following21cases, control group to visit the hospital without concomitant ED in30diabetic patients, aged49to53years, mean44.67+/-8.7years, two groups of patients with age, duration of diabetes with no statistically significant difference (P>0.05), have good comparability. All study subjects were excluded patients with coronary heart disease, hypertension, cerebral infarction and other diseases of peripheral neuropathy, and exclusion taking antihypertensive drugs, hormones and antidepressants. In the fasting state extraction in patients with elbow vein blood for detection of lipoprotein (a); nitric oxide (NO); malondialdehyde (MDA), and the use of prostaglandin E after intracavernous injection, using color Doppler ultrasonography on penile corpus cavernosum arterial diameter (CAD), determination of penile deep artery flow maximum (peak systolic velocity, PSV) were measured and recorded. The group T test analysis of two groups of patients among different indicators of differences, and further using Spearman correlation analysis of serum markers and IIEF-5, CAD and PSV correlations between.[Results] diabetic patients in the ED group laboratory index LP (a) and MDA was significantly higher than the control group, there was significant difference of statistical significance (P<0.01), and NO levels were significantly lower than those in the control group, there was significant difference is statistically significant (P<0.01), ICI experiments CAD thickening percentage and PSV diabetic ED group of patients was significantly lower than the control group, there was significant difference is statistically significant (P<0.01), and through the Spearman correlation analysis found that LP (a) and PSV (r=-6.24, P<0.01); CAD thickening ratio (R=-8.20, P<0.01), IIEF-5(r=-8.11, P<0.01) score showed negative correlation with PSV, NO (r=6.56, P<0.01); CAD thickening ratio (r=7.56, P<0.01), IIEF-5(r=6.34, P<0.01) scores were significantly positive correlation, MDA and PSV (r=6.98, P<0.01); CAD thickening ratio (r=7.45, P<0.01), IIEF-5(r=-7.54, P<0.01) score showed a significant negative correlation[Conclusion]1Patients with diabetes mellitus serum LP (a) increased significantly (a, LP) resulted in elevated penile corpus cavernosum arterial stiffness may be the result of patients with diabetes mellitus erectile dysfunction is one of the risk factors.2Patients with diabetes mellitus serum NO was significantly elevated, elevated NO cause may be the cause of diabetic patients with neurogenic erectile dysfunction is one of the risk factors.3Patients with diabetes mellitus tissue oxygen free radical oxidation of MDA increased, significantly enhance the capacity, oxidative stress may be diabetic erectile dysfunction and biochemical levels is one of the factors, and the MDA test can reflect the level of oxidative stress in the body.4Diabetes mellitus with ED is a complex pathophysiological process, involving vascular, neural, endocrine and psychological and other factors, so the LP (a), NO and oxidative stress in diabetic patients with ED process just leads to the onset of the main threat factors, or by other factors remain to be further research.