Association Between GJB2Gene Polymorphism And Patients With Psoriasis

ObjectiveTo investigate the association between GJB2rs3751385and psoriasis susceptibility in south Chinese population and test Cx26levels in the plasma of psoriasis patients and controls.MethodsWith case-control assay, we investigated the polymorphisms of GJB2rs3751385in371psoriasis patients and330healthy controls in south Chinese population using a polymerase chain reaction restriction fragment length polymorphism assay (PCR-RFLP). The plasma levels of Cx26in55psoriasis patients and65normal controls were assayed by enzyme-linked immunosorbent assay.Result1. Genotype frequencies of GJB2rs3751385CC, CT and TT genotypes in patients group were21.56%,53.64%,24.80%respectively, while in controls were36.67%,44.85%,18.48%. Significant distinction was observed in genotype distribution of rs3751385polymorphism (p=4.99×10-5) between cases and controls. Case-Control assay indicated a significant decreased frequency of the GJB2rs3751385C allele in psoriasis patients compared with controls (p=6.02×10-5, Odds ratio [OR]=0.793,95%confidence interval (CI):0.706-0.889).2. The Cx26level was significantly decreased in the plasma of psoriasis patients compared with controls (p=1.96×10-5) and was negatively correlated with psoriasis area and severity index score (PASI)(r=-0.247, p=0.036).Conclusion1. GJB2gene polymorphisms rs3751385was associated with south Chinese population psoriasis susceptibility.2. Cx26plasma concentration of psoriasis was significantly lower than the controls, and was negatively associated with the clinical severity of psoriasis.