| Objection:Transient receptor potential channel-related protein1(TRPC1), is a non-selective calcium channel, prominently expressed in cell membrane and cytoplasm of adult heart, muscle, brain, testis and ovary tissue. TRPC1can be activated by depletion of intracellular Ca2+pools and induces extracellular calcium influx, then causes a variety of biological function, involved to the stability of intracellular and extracellular calcium and cell signal transduction.Methods:Tissue samples and clinical date of this study were obtained from50patients with Hepatocellular Carcinoma (HCC) who underwent hepatectomy between2005to2009in Department of Liver and Gallbladder Surgery, Xiangya2nd Hospital, Central South University. The express of TRPC1was assessed by immunohistochemistry in the study. In addition, the correlations between expression of TRPC1and clinicopathological parameters, including the histopathological differentiation, tumor size and number, portal vein invasion were all analyzed.Results:Immunohistochemistry of50HCC samples showed that high expression of TRPC1was observed in29/50(58%), and low expression is observed in21/50(42%). In addition, clinicopathological evaluation indicated a significant correlation between high expression of TRPC1and clinicopathological parameters of histopathological differentiation, portal vein invasion, but no significant correlation with tumor size and number, age and sex.Conclusions:The results above suggests that TRPC1may play a role in hepatocarcinogenesis。... |
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