Association Studies Between The CYP450-2E1Genetic Polymorphism And Anti-tuberculosis Drugs Induced Liver Injury

Objective: To investigate the susceptible factors of the occurrence ofantituberculosis drug-induced liver injury (ATLI) and to study the relationsbetween ATLI and genetic polymorphism of cytochrome CYP2E1. Method:With the aid of nested case-control study, Relative risk factors werestatistically analyzed and inferred according to the case-control study.Analyze the genetic polymorphism of cytochrome CYP2E1in the case-controlstudy using PCR-LDR method, and analyze the relations between the geneticpolymorphism and ATLI. Result:1.Among the1505patients in the cohort,65patients had ATLI, with the incidence being4.32%.2. Univariate analysisresults showed that there was significant difference in gender, HBsAg, historyof liver diseases, history of smoking, history of drinking, treatment programsand etc (p<0.05).Multivariate non-conditional logistic regression analysisshowed that gender, history of liver diseases, HBsAg, history of smokingwere risk factors, and OR were2.187(OR95%CI:1.224~3.906),3.046(OR95%CI:1.586~5.851),2.192(OR95%CI:1.282~3.749),2.149(OR95%CI:1.009~4.580).3. In the sample of1073cases of Uighurpatients CYP2E1genotype with Hardy-Weinberg equilibrium test, the test toachieve the the H-W balance (2=3.602, P=0.057).CYP2E1genepolymorphism was no significant difference between gender, ethnicity, agedistribution. In Uighur population, the C1/C1, C1/C2, C2/C2genotypedistribution in case group and control group not statisticallysignificant.Conclusion: The incidence of ATLI in patients with tuberculosisin Xinjiang Region was4.32%. History of liver diseases, gender, HBsAg wererisk factors. In conclusion, during antituberculous treatment for patients withtuberculosis, liver function should be monitored, and patients with possible risk factors should be closely observed.