The Analysis Of Correlative Factors Of In-Stent Restenosis After Coronary Stent Implantation

Objective:To analysis the factors of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with Coronary heart disease (CHD) for offering theory with preventing restenosis.Methods:One year’s follow-up of coronary angiography after percutaneous coronary intervention (PCI) was performed in797patients from February in2005to August in2010. In stent restenosis (ISR) was defined as luminal diameter narrowing of intracoronary stent by50%or greater. According to the results of coronary angiography,797patients were divided into two groups:restenosis group (153patients) and control group (644patients). The differance of relationship between clinical data and biochemical parameters and angiography results between two groups were analyzed retrospectively, we use univariate and multivariate logistic regression analysis to indentify the relationship between factors and ISR.Results:The statistic differences were found in diabete mellitus, serum uric acid, serum total bilirubin (TBIL), the stent diameter. The ISR group showed a significantly higher rate of diabetes mellitus than that in control group [34.64%vs23.91%, P=0.007]. The ISR group showed a smaller stent diameter than that in control group (2.90±0.41mm vs3.02±0.90mm, P=0.002). The level of serum uric acid was significantly higher in restenosis group than that in control group (406.54±78.18umol/L vs343.78±76.64umol/L, P=0.000). The baseline TBIL level was significantly lower in patients with ISR than that in control group (11.70±4.71umol/L vs13.16±6.43umol/L, P=0.008). In the multivariate logistic regression analysis model, hyperuricemia (OR=1.653,95%CI1.447-2.083), diabetics (OR=2.340,95%CI1.893-3.011) were independent risk factors of in-stent restenosis. The stent diameter (OR=0.668,95%CI0.496-0.980), the TBIL level (OR=0.838,95%CI0.797-0.980) were protective factors of in-stent restenosis.Conclusion:Diabetics, the stent diameter, serum uric acid level, serum total bilirubin level wre correlated with in-stent restenosis. The ISR group showed a significantly higher rate of diabetes mellitus and serum uric acid than that in control group. Diabetics mellitus and hyperuricemia were independent risk factors of in-stent restenosis. The stent diameter and baseline TBIL level were significantly lower in patients with ISR than that in control group. The larger stent diameter, the TBIL level were protective factors of in-stent restenosis.