Study On The Relationship Between Bilirubin And Serum Uric Acid And The Severity Of Coronary Artery Disease

Objective: to investigate the relationship between bilirubin and serum uric acid levels and the degree of coronary atherosclerosis stenosis.Methods: a total of 461 patients undergoing coronary angiography between January 2015 and December 2016 in Sihong People’s Hospital were selected.All the enrolled subjects were measured serum bilirubin,serum uric acid and other related biochemical parameters on the morning of second day after admission,and the related clinical data of the patients were recorded.According to the results of coronary angiography in patients,344 cases of major vascular or branch stenosis ≥50% were treated as CHD group while 117 cases of stenosis〈50% were treated as non CHD group.The levels of serum bilirubin and serum uric acid in the two groups were analyzed.The clinical data,including smoking history,age,sex,blood pressure,blood lipid,blood glucose and other indicators were statistically analyzed.Results: The concentration of bilirubin in CHD group(10.83±3.29mmol/L)was lower than that in control group(14.05±4.09mmol/L),and the concentration of serum uric acid(346.65±94.14umol/L)in CHD group was higher than that in control group(287.75±76.99umol/L).The difference between the two groups was statistically significant(P<0.05);The number of patients with smoking,hypertension,hyperlipidemia and diabetes mellitus in CHD group was significantly higher than that in non CHD group,and the difference was statistically significant(P<0.05);The degree of coronary artery stenosis was positively correlated with serum uric acid,and negatively correlated with total bilirubin level,and the difference was statistically significant(P<0.05).However,it was not correlated with indirect bilirubin and direct bilirubin levels,and the difference was not statistically significant(P<0.05);Logistic regression analysis showed that total bilirubin and serum uric acid levels were the influencing factors of coronary artery disease.Among them,the significance of total bilirubin level was higher,and the value of OR was the highest,6.732.The 95%CI was 1.589-37.615.Hyperlipidemia,hyperglycemia and hypertension are the high-risk factors of coronary atherosclerosis.Conclusion:In patients with coronary artery disease,the levels of blood TBIL and UA vary with the increased severity of coronary artery disease or the increased number of vascular lesions.With the severity of coronary atherosclerotic stenosis,the level of UA increased gradually,while the level of TBIL decreased gradually.With the number of vascular lesions,the level of UA increased gradually,while the level of TBIL decreased gradually.The levels of serum TBIL and UA in patients with coronary heart disease were related to the severity of coronary artery lesions and the number of vascular lesions.Among them,the levels of UA were positively related to the severity of coronary artery lesions and the number of vascular lesions,but the levels of TBIL were negatively correlated with them.Therefore,blood TBIL and UA may provide new and feasible biochemical indicators for the diagnosis and treatment of coronary heart disease;It also suggested that early intervention of bilirubin and serum uric acid levels may have a protective effect on coronary arteries and prevent cardiovascular events.