| Objective: Langerhans cell histiocytosis (LCH) is a rare disease characterized byproliferation and accumulation of pathologic Langerhans cells, which can infiltratesmultiple organs. The clinical manifestations and spectrum of vary depending on theorgan(s) involved. Cases about the LCH of the liver are reported infrequently. Theaim of the following paper is to analyze the characteristics of LCH involves in liver.Methods: We reviewed the records of13patients who were treated for LCH of theliver in Wuhan Union Hospital during Aug.2005and Aug.2011, retrospectivelyanalyzing the incidence of different organs, characteristics, examination results andthe prognostic features. The follow-up information was collected via telephones.Results: The13patients had multisystem disease. The LCH was found in liver at riskof involvement but the first symptom of the most cases is not the liver lesion. Thehepatic examinations manifested liver enzymes elevated for unexplained (92.3%),hepatic space-occupying lesions (69.2%) and hepatomegaly (61.5%).Conclusion: When LCH infiltrates the liver, it has a propensity lesion for theirreversible biliary ducts, secondary to sclerosing cholangitis, biliary cirrhosis, hepaticfailure, even death. when the unknown cause unexplained recurrent liver dysfunction,hepatic space-occupying lesions, hepatomegaly with diabetes insipidus, skin rashand bone destruction, should consider that LCH is possible. With or without liverinvolvement is an important risk factor affecting prognosis in LCH, it isrecommended that the diagnosis of liver specific examination in patients with LCH,should be given to early detection and treatment... |
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