The Design And Achievement Of Ultrasound-guided PHIFU Software System

High intensity focused ultrasound (HIFU), which is truly non-invasive,has been clinically recognized as an efficient physical therapy modality.The main principle of HIFU is that the high-energy ultrasound beams invitro are focused to the target tissues of human body and then make thetemperature, at the focus of the target tissue, to rise to above56℃withinseconds. A clinical benefit of HIFU technology is the tissue coagulationnecrosis is produced during per-operative procedure without affecting thesurrounding normal tissue. In a similar design of radar phased array,phased high-intensity focused ultrasound (pHIFU) achieves the focusingand deflection of the ultrasonic beams, by means of modulating ultrasonicamplitude and phase of the drive signal from every element of phasedarray. Since no mechanical movement is needed, the switching betweenthe different focus modes is much more convenient, and thus becomes veryfast. Medical imaging system guided high intensity focused ultrasoundsystem carries out pre-operative localization, intra-operative monitoringand post-operative evaluation of the target tissue based on the imagecontent in order to effectively complete the target ablation. CurrentlyImage-guided mode is mainly divided into two types: ultrasound imaging,and magnetic resonance imaging.This research work mainly addressed software design andimplementation of an ultrasound-guided phased high intensity focusedultrasound treatment system, and conducted the following researchproblems:Firstly, by investigating the literature and existing commercial modelsabout ultrasound guided phased high intensity focused ultrasound system,the image-guided procedure is determined in such a way that treatment images is perpendicular to ultrasound monitoring images, and guidedprobe starts rotation scan around ultrasound propagation axis. A softwaresystem solution is identified by using C#language and WPF UI frameworkand MVC software design patterns. This software framework can achievereal-time access to ultrasound image and timing storage, as well as thecommunication between master controlled machine and worker controlledmachine.Secondly, in terms of the pHIFU demand for multi-modal medicalimages, we design software service middleware for DICOM medicalimages sending, receiving and interaction with algorithm system.As a windows service application program, the software service can beable to automatically listen and detect. Combined with the adapter designpattern，we design DICOM image input and output adapters which canachieve selective storage of DICOM images, interact with algorithmsservice modules, and output the results.Thirdly, we conducted3D reconstruction of ultrasonic images for theuterine leiomyoma target tissue region according to the image guidedworkflow as well as exploited the cross-sectional images to form atreatment plan in three-dimensional reconstruction images. Detailed workincludes3D directional filtering, context quantization enhancement onimages got by rotating span, and fan span reconstruction which iscompleted by designing structure table by means of hyperbolainterpolation method. Finally, the3D image visualization functionsincluding volume rendering, surface rendering, maximum and minimumvalues rendering are also developed by using the most simple Ray-castinglight synthesis method.