Children With Hand-foot And Mouth Disease On Immune Function

ObjectiveDiscussion on the cell immune function in children with hand foot and mouth disease and pathogenesis, its relation to disease severityObject:The research object for the2009May to2011September Ji’nan city children’s hospital admission of354cases of children with hand foot and mouth disease. Male228cases, female126cases, the ratio of men to women:June1; age1.8to6years, average2.3years old,209patients aged<3.Methods:2009May to2011September were collected in Ji’nan children hospital admitted354cases of children with hand foot and mouth disease clinical data, According to the condition is divided into mild group (no encephalitis group) in159cases, severe group (195cases with encephalitis group), On the same time, peer health check in children100cases as control group. By flow cytometry using single platform T cell subsets (CD3, CD4, CD8) percentage detecting, And the same age healthy children were compared.Results and analysis:Foot and mouth disease in children with T cell subsets detection value and the control group comparison of normal values of CD3, CD4, CD8:detection values were significantly lower, the difference was statistically significant (p=0.001). In group CD3, CD4, CD8T cell number and mild group comparison, more decreased, Especially the coma and neurogenic pulmonary edema in children with critically ill patients decreased more obviously, the difference was statistically significant (p=0.001). CD3/CD4in mild and severe compared between the two groups, the difference was not statistically significant (p=0.9195).Conclusion:Children with hand foot and mouth disease is obviously low cell immune function, and immune regulation function are disorder, tips on hand foot mouth disease, attention should be paid to immune supportive treatment.