Clinical Curative Effect Of Combined Terbutaline And Budesonide For Inhalation In The Treatment Of Bronchiectasis

Objective:By observing the clinical efficacy of atomization inhalation of a short-acting β2-agonist (terbutalin) and corticosteroid (budesonide) in combination therapy of bronchiectasis, to seek a new method of treatment for bronchiectasis.Method:We choose70patients who were diagnosed as acute exacerbation bronchiectasis and in line with inclusion criteria in the respiratory department of The First Hospital of Jilin University from Jan.2012to Mar.2013. The patients were assigned randomly into2groups, the control group and the treated group were both35cases. The control group received conventional therapy such as oxygen inhalation, anti-inflammation, relieving cough, reducing sputum and atomization inhalation normal saline. The treated group received atomization inhalation terbutalin and budesonide twice per day on the base of conventional therapy, and the observation was done for7days. The clinical efficacy(cough, expectoration quantity, rale), the pulmonary function (FEV1, FVC, FEV1/FVC, PEF), ESR and CRP were compared between the before and after treatment.Result:1.In clinical efficacy:The control group,12cases of particularly effective (34.29%),17cases of effective (48.57%),6cases of invalid (17.14%), the total efficiency is82.86%; The treated group,22cases of particularly effective (62.86%),11cases of effective (31.43%),2cases of invalid (5.7%), the total efficiency is94.29%. Differences between two groups was statistically significant (P<0.05), the treated group is significantly better than the control group.2.Pulmonary function:The FEV1, FVC, FEV1/FVC, PEF of the dissertation is improved in both groups(P<0.05). The treated group is significantly better than the control group(P<0.05).3.ESR and CRP:There is a decrease of ESR and CRP in both groups, the difference was statistically significant(P<0.05). The variation of the treated group is significantly higher than the control group(P<0.05).4.Throughout the process,2cases of the treated group felt nausea and pharynx unwell after atomization inhalation. Instruct the patients to take a rest during the atomization inhalation and rinse the mouth after the atomization inhalation. The symptoms were relief. The adverse reaction cases of the treated group than the control group was no significantly different(P>0.05).Conclusion:1.Combination of atomization inhaling of terbutalin and budesonide might improve the clinical efficacy for acute episode phase patients with bronchiectasis.2.Combination of atomization inhaling of terbutalin and budesonide might improve the pulmonary function for acute episode phase patients with bronchiectasis.3.Combination of atomization inhaling of terbutalin and budesonide might decrease the level of ESR and CRP for acute episode phase patients with bronchiectasis and promote the recovery of acute airway infection.4.Combination of atomization inhaling of terbutalin and budesonide to treat bronchiectasis was safe and effective.