The Ma Fu Pingchuan Granule Pharmaceutical Research And Preliminary Exploration Of Pharmacodynamic

The Mafu pingchuan granule prescription is composed by clinical trials and clinical screening, application of many years of clinical curative effect. Ephedra, cinnamon, Rehmannia, Chuanxiong. Monkshood, Mustard Seed, ginger, licorice, all-Bawei drug composition, with a kidney and asthma, the effect of warm the lung of drink. Active ingredient according to the prescription of herbs and their efficacy, pharmacology and other basic research, combined with pharmacodynamic test initial screening of the extract process route, the application of modern extraction, separation technology, to extract the active fractions, combined with advanced molding process, the system into granules. The specific research topics include the following aspects. Theoretical research:the theory of Chinese medicine as a guide to explain the basis and significance of the source of the party and established title, while the right prescription medicine contained in the chemical composition and physicochemical properties of induction and conclusion.First,theoretical research:the theory of Chinese medicine as a guide to explain the basis and significance of the source of the party and established title, while the right prescription medicine contained in the chemical composition and physicochemical properties of induction and conclusion.Sencond,study on Preparation:To determine the medicinal varieties of herbs ephedra feeding, selection of equisetina feeding; determine Chen medicine with a piece of the boiling time, the experiment found the Monkshood Xianjian1.5h after the diester alkaloids have been partially hydrolyzed into less toxic or non-toxic ingredients.Pharmacodynamic test initial screening to determine the extraction process line:Monkshood boiling first1.5h with ephedra and prescription of Chinese herbal medicines such as total water extraction, liquid by separation and purification, made from dried extract powder.Yield trials in order to extract ephedrine content as an index, using orthogonal experimental optimization of ephedra and other herbs, the best extraction process: plus eight times the amount of water, extracted three times, each time1.5 hours. Extraction of the liquid in the separation and purification, the comparison of high-speed centrifugation and alcohol precipitation process, the best screening process: liquid decompression concentrated to a relative density of1.25(60℃), with60%ethanol concentration of alcohol precipitation alcohol precipitation placed24h. The purified liquid extract powder made by vacuum concentration, vacuum drying.Parallel experiments, combined with the particles forming rate preferred type and ratio of the best accessories to improve the moisture resistance of extract powder, and finalized the preparation of the molding process.Third,preliminary study of quality standards and stability test:control of the product quality of raw materials and finished product quality standards. Identified by TLC ephedra preparations, Chuanxiong, licorice, ginger, cinnamon and HPLC method was used for a limited check diester alkaloids toxic components; HPLC determination of preparations of ephedrine and pseudoephedrine content. Stability studies, to stay kind of observation to examine the stability of hemp attached and asthma particles, indicating that the preparations in clinical drug packaging, drug properties and stability in the six months.Fourth,pharmacodynamics and acute toxicity study:drug toxicology studies of the acute toxicity test as well as cough, phlegm, and asthma efficacy studies in order to provide the efficacy of asthma and asthma particle therapy for the clinical application of Ma attached school basis.