The Research Of Expression And Clinical Significance Of P53,Ki-67,PCNA In Gastrointestinal Stromal Tumor

Objective:This study aimed to investigate the expression of P53, Ki-67, and PCNA in gastrointestinal stromal tumor, and explore their relationship with gastrointestinal stromal tumor.Methods:IHC were used to investigate the expression of P53, Ki-67, PCNA in the specimens of gastrointestinal stromal tumor. The correlations between P53, Ki-67, PCNA and clinicopathologic features, and prognosis of gastrointestinal stromal tumor were analyzed.Results:1. The P53expression had a significant correlation with NIH intermediate risk and NIH high risk (P<0.05). The expression rates of P53were not related to sex, age, location, size of tumor, tumor size, cell type and necrosis, but have a close relation with the mitotic count more than5/50HPF.2. The Ki-67expression had a significant correlation with NIH intermediate risk and NIH high risk (P<0.05). The Ki-67expression was not related to sex, age, location, mitotic count, cell type and necrosis, but has a close relation with the tumor size more than5cm.3. The PCNA expression was not related with any NIH risk group (P>0.05). Similarly, the PCNA expression was not related to sex, age, location, size of tumor, mitotic count, cell type and necrosis.4. The P53expression have a positive correlation with the Ki-67expression (correlation coefficient:+0.005, P<0.05). The P53expression did not have a correlation with the PCNA expression (correlation coefficient:+1.000, P>0.05). Similarly, the expression of Ki-67did not have a correlation with the PCNA expression (correlation coefficient:+0.370, P>0.05).Conclusions:P53and Ki-67expression were both increased when the gastrointestinal stromal tumor progressed which means they may relate to the malignancy of tumor. P53and Ki-67may be valuable marker for assessing the prognosis of gastrointestinal stromal tumor.