| Objective:1. To investigate the detection ratio and the imaging features of coronary atherosclerotic plaques in asymptomatic people:2. To analyze and compare the role of coronary atherosclerotic plaques with different properties and morphology in the cause of degree of coronary artery stenosis in asymptomatic people;3. To evaluate the relationship between the degree of coronary artery stenosis and blood glucose and lipid concentration in the patients with coronary atherosclerotic plaques.Materials and methods:Among the271patients for CTCA in physical examination center of Sichuan academy of medical sciences&Sichuan provincial people’s hospital from July1st2011to February29th2012,268cases with corresponding image quality were retrospectively analyzed. Among them.230cases were male and38cases were female. Conventional method was used in CTCA examination:according to the NYHA classification, the coronary artery tree was broken down into15segments. Based on the presence of calcification, the coronary atherosclerotic plaques were classified into3types:the non-calcified plagues, the calcified plagues and the mixed plagues. Based on morphology, the plagues were divided into type I plagues, type II plagues and type III plagues. And the coronary artery stenosis caused by atherosclerosis was classified into degree1with mild stenosis (<50%). degree2with moderate stenosis (50%<degree of stenosis<75%) and degree3with severe stenosis (≥75%). The relations between the degree of coronary artery stenosis and blood glucose and lipid concentration in the asymptomatic people were statistically analyzed.Results:1.271patients were included, and due to that3cases had bad image quality,268patients in total were included for image analysis. The mean age was47.88±9.38years old.230cases were male with mean age being47.73±9.40years old. and38cases were female with mean age being48.76±9.20years old. Among the268patients 70cases (26.12%of the total) had coronary arterial lesions with129plagues being detected. In the male group,164cases (71.30%of male cases) had no detected plagues, and66cases (28.70%of male cases) had detected plagues with123plagues in total (95.35%of the total plagues). In the female group,34cases (89.47%of female cases) had no detected plagues, and4cases (10.53%of female cases) had detected plagues with6plagues in total (4.65%of the total plagues).2. Atherosclerosis was mainly found in proximal main coronary artery, and the incidence was much higher in the proximal and middle section of left anterior descending coronary artery. Among them,64(49.61%) were found in the left anterior descending coronary artery.3.129plagnes in total were detected. According to the property, the plagues were divided into3types:52non-calcified plagues (40.31%of the total),44calcified plagues (34.11%of the total) and33mixed plagues (25.58%of the total). Based on morphology, the plagues were divided into type I with84plagues (65.12%of the total), type II with31plagues (24.03%of the total) and type III with14plagues (10.85%of the total). There was significant difference in the morphology of plagues with different properties (P<0.001). And there was significant difference in the degree of stenosis caused by plagues with different morphology (χ2=45.4170, P<0.001). And also there was significant difference in the degree of stenosis caused by plagues with different properties (χ2=11.2763,P=0.004)4. Analysis the different properties of the plagues caused the most stenotic sites between the CHD and non-CHD groups. The results showed that there was significant difference (χ2=7.132,P=0.028).5. The age of patients with different degrees of coronary artery stenosis was analyzed for the difference, and statistical results showed that there was significant difference (P=0.01)6. The relations between the degrees of stenosis in the most stenotic sites and blood glucose, total cholesterol. TG LDL. and HDL concentrations were analyzed, and results showed that the five indicators and the degree of coronary artery stenosis had no linear correlation(P>0.05). Conclusion:The detection ratio of atherosclerotic plaques in asymptomatic people with DSCT was26.12%. and male patients had a higher ratio than female patients. The age of patients with degree3stenosis was much higher than that of patients with degree] and degree2stenosis. The degree of stenosis caused by plagues with different properties and morphology had significant difference. There was significant difference between the properties and morphology and the property of plagues, and type II plagues were mainly non-calcified ones. The property of plagues causing coronary heart disease had significant difference. The degree of stenosis had a positive correlation with the blood glucose, total cholesterol. TG, and LDL concentrations, and had a negative correlation with HDL-C. but they had no linear correlation. |
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