Interconnectivity Between The Reaction System Of Myeloperoxidase And Vessel Disease In Patients With Unstable Angina Pectoris And Hypertension

Objective: To investigate the interconnectivity between the reaction system ofmyeloperoxidase and vessel disease in patients with unstable angina pectoris andhypertension.Methods: A total of64unrelated Han Chinese subjects in Northeast China wereenrolled in this case-control study. We measured MPO level and biomarkers ofoxidative stress related to MPO, such as H2O2, LDL-HNE, GSH, T-AOC etc.Moreover, we analyzed the correlations between the reaction system of MPO, levelsof other biomarkers of oxidative stress and vessel disease in patients with unstableangina pectoris and hypertension by Spearman’s correlation. We analyzed thedistribution of biomarkers of oxidative stress in the reaction system of MPO, and thereaction system of MPO Contribute to vessel disease in patients with unstable anginapectoris and hypertension.Results: In the peroxidation system of MPO, LDL-HNE level is increased withthe increase of H2O2level and MPO level when H2O2level is between1-11uM andMPO level is between0-7U/L; hs-CRP level is increased with the increased of H2O2level and MPO level when H2O2level is between4-10uM and MPO level is between2-7U/L; the degree of vascular lesions tended to increase with the increase of H2O2level and MPO level when H2O2level is between6-11uM and MPO level is between4-7U/L. In the chlorination system of MPO, Protein carbonylation level is increasedwith the increase of Cl-level and reduce of MPO level when Cl-level is between106-114mmol/L and MPO level is between2.5-7U/L. The degree of vascular lesionstended to increase with the reduce of Cl-level and increase of H2O2level in thereaction system of MPO.Conclusions: The degree of vascular lesions tended to increase with the reductionof Cl-level and increase of H2O2level in the reaction system of MPO（P＜0.05）.H2O2level has a significant contribution to LDL-HNE level in the peroxidation Systemof MPO, and H2O2level has a significant contribution to the degree of vascular lesionsin the reaction system of MPO（P＜0.05）. The interaction of MPO activity has asignificant contribution to Protein carbonylation in the chlorination system（P＜0.05）.H2O2level has a significant correlation with Hs-CRP level in the peroxidation System of MPO（P＜0.05）.