The Correlation Between Vascular Vertigo And Oxidative Stress And Inflammatory Reaction

Objective: Vascular vertigo refered to insufficiency of labyrinthine artery is a vascular disease which is caused by vestibular system dysfunction. Posterior circulation ischemia caused by atherosclerosis is the primary pathogeny in vascular vertigo. Vascular endothelial injury, oxidative stress and inappropriate expression of inflammatory factors play a very important role. It is reported that oxidative stress and inflammatory factors can be related with atherosclerosis, and we speculate the relation between vascular vertigo and oxidative stress/inflammation. This study analysed serum IL-6, TNF-α, SOD, MDA and CD62 P in patients having got vascular vertigo and aimed to explore the correlation between IL-6, TNF-α, SOD, MDA, CD62 P and vascular vertigo respectively and its clinical significance, in order to provide reference for further studies about the mechanism on pathogenesis of vascular vertigo and for the diagnostic value of vascular vertigo.Methods:1Vascular vertigo group: 52 patients with vascular vertigo were selected, it included 23 males and 29 females, and mean age was(64.44±10.71) years old. Inclusive criterion: a) Patients’ chief complaint was vertigo or dizziness, patients may be with or without symptoms such as numbness of extremities and face, paralysis, paraesthesia, dystaxia, articulation disorder, dysphagia, drop attack, hemianopsia etc; b) there was an evidence about insufficiency of vestibular system, definitive diagnosis of haemodynamic abnormalities, stenosis, occlusion of vertebro-basilar artery/posterior cerebral artery.2 Non-vascular vertigo group: such as benign paroxysmal positionalvertigo, Meniere’s disease, vestibular neuritis and others that chief complaint was vertigo, there were no evidence for vacular impairment in these diseases.It included 17 males and 21 females, and mean age was(62.45±12.91) years old.3 Control group: 40 healthy people who were under physical examination and never suffered from vertigo in the past. It included 18 malesand 22 females, and mean age was(65.43±7.15) years old.This study employed enzyme-linked immine quantitative analysis method to measure the serum concentration of IL-6, SOD, MDA and TNF-α, and monoclonal antibody fluorescence method to measure the activating rate of CD62 P, and compared among groups, then probed clinical diagnosis value about oxidative stress and inflammatory reaction in vascular vertigo and the probable pathogenesis about vascular vertigo.Results:1 The serum IL-6 concentrations of vascular vertigo group, non-vascular vertigo group, and control group were(20.193±10.672)pg/ml,(15.697±4.386)pg/ml,(14.205±3.112)pg/ml respectively. TNF-α concentrations of vascular vertigo group, non-vascular vertigo group, and control group were(17.316±3.351)pg/ml,(15.322±3.920)pg/ml,(14.395±3.242)pg/ml respectively. The serum IL-6, TNF-α concentrations of vascular vertigo group was higher than non-vascular vertigo group and control group, there was a significant difference statistically, and there was no significant difference statistically between non-vascular vertigo group and control group.2 The serum SOD concentrations of vascular vertigo group, non-vascular vertigo group and control group were(54.34±3.34) U/ml,(61.38±6.66)U/ml,(68.96±6.13) U/ml respectively. The serum MDA concentrations of vascular vertigo group, non-vascular vertigo group and control group were(5.96±2.07) nmol/ml,(3.61±0.12) nmol/ml,(3.96±0.36) nmol/ml respectively. The serum SOD/MDA concentrations of vascular vertigo group was lower/higher than non-vascular vertigo group and control group, there was a significant difference statistically, and there was no significant difference statistically between non-vascular vertigo group and controlgroup.3 The activating rate of CD62 P in vascular vertigo group, non-vascular vertigo group and control group were(34.770%±12.627%),(30.160%±8.148%),(27.341%±3.290%) respectively. The activating rate of CD62 P in vascular vertigo group was higher than non-vascular vertigo group and control group, there was a significant difference statistically, and there was no significant difference statistically between non-vascular vertigo group and control group.4 The serum TNF-α concentrations of vascular vertigo had positivecorrelation with LDL, but the correlation was low(P=0.028, r=0.305).Conclusions:1 The level of serum IL-6, TNF–α in patients of vascular vertigo increased, and which promped inflammation and inappropriate expressionof inflammatory factors and might involve in the occurrence of vascular vertigo.2 The level of serum MDA in patients of vascular vertigo increased, and the level of serum SOD decreased, and that prompted the imbalances of oxidation and antioxidant, lipid peroxidation and which might contribute to vascular vertigo.3 The level of activating rate of CD62 P in patients of vascular vertigo increased, and it prompted platelet activation may be closely relatedwith the occurrence and development of vascular vertigo.4 Inflammation may lead to abnormal lipids metabolism so as to form vascular vertigo.