Clinical Research On Refractory Ascites Of Cirrhosis Treated By The Therapy Of Tonifying Spleen, Removing Stasis And Alleviating Water Combined With Ultrafiltration, Concentration And Peritoneal Reinfusion Of Ascites

Objective:To observe the effect of the therapy of tonifying sp-leen,removing stasis and alleviating water combined with ultra-filtration,concentration and peritoneal reinfusion of ascitesrefractory ascites due to cirrhosis.Evaluated the safety of thetreatment on refractory ascites due to cirrhosis objectively.Methods: collected60patients with refractory ascites of cirr-hosis who were in accordance with the inclusive criteria(All thepatients were treated in traditional chinese medicine hospitalof Hubei province from Aug2010to Feb2012).Patients were equallydivided into two groups by software SPSS16.0. patients of thecontrol group were treated by ultrafiltration, concentration andperitoneal reinfusion of ascites based on the routine therapy.patients of the treated group were treated by traditionalprescription(based on the therapy of tonifying spleen,removingstasis and alleviating water in addition to the treatment of thecontrol group.The courses of treatment both were four weeks,thetreatment of ultrafiltration, concentration and peritoneal rei-nfusion of ascites every two weeks.The ascitic volume of ultraf- iltration from3,000ml to10,000ml according to pathogeneticcondition of patients. Observed24hours urinary output a weekpretherapy and posttreeatment cardinal symptom,signs, weight,ab-dominal girth,liver function prothrombin time,splenic thickness,diameter of portal vein pretherapy and posttreatment to analysethe effects of clinical treatment.Observed vital signs(T,P,R,BP),blood routine,urine routine,stool routine,renal function,ECG andadverse reactions of drugs to evaluate the safety of the resea-rch.Patients were followed up3months after a period of treatment.Results: The total effective rate of the treated group was93.33%,The total effective rate of the control group was86.66%.Comparedwith control group,the treated group had significantly bettereffect on overall clinical curative effect.The results of twogroups’symptom integral:compared with control group,the treatedgroup had significantly better effect on fatigue and abdominaldistension(P<0.05),there were not significant difference in poorappetite, edema of lower extremity,jaundice,the block forflank,abdominal wall varicosis(P>0.05).Compared with controlgroup,the treated group had significantly better effect onweight,abdominal girth,24hours urinary output (P<0.05).Both thetwo groups had positive effect on ALT,AST and TBIL.Compared withcontrol group,the treated group had significantly better effect onALT and ALB(P<0.05),There were not significant difference in ASTand TBIL(P>0.05).There were not significant difference in prot-hrombin activity(PTA),splenic thickness,diameter of portal vein(P>0.05).Compared with control group,the treated group had sig-nificantly better effect on ascites subsided situation(P<0.05).Conclusion:The therapy of tonifying spleen,removing stasis and alleviating water combined with ultrafiltration and peritonealreinfusion of ascites treated on refractory ascites of cirrhosiscould promote ascites subsided,improve patients’clinical symptomsuch as fatigue,abdominal distension,also could improve patients’life quality.The clinical curative effect was distinct.