| Objective:Depressed patients is not only characterized by significant and lasting low mood,decreased interest, lack of pleasure, and in recent years a large number of studies have shown that there are cognitive dysfunction in people with depression, which may be one of the factors that affect the social function of patients. Currently antidepressant drugs mainly aimed at the improvement of the core symptoms of depression patients, there is no special efficient drugs to improve cognitive function in patients with depression. So this study is to observe the changes of cognitive function and quality of life in patients with depression before and after application of antidepressant drugs, and to analysis of the relationship between the degree of depression and cognitive function, quality of life.Method:1. ObjectDepressive group:61cases, were sampled from outpatient of Department of Neurology, Qilu hospital of shandong university from April2012to December2012. Control group:46cases, were mainly sampled from examinees of Medical examination center of Qilu Hospital and the family members of other diseases patients from outpatient or ward of Qilu Hospital.2. Treatment and Scale SurveyThe depression patients were given paroxetine20mg, po, qd. Evaluate the degree of depression by Hamilton depression rating scale (HAMD17), assess cognitive function with the Montreal cognitive assessment scale cognitive assessment (MoCA), evaluate the quality of life by the world health organization quality of Life (WHOQOL-BREF). The assessments of HAMD, MoCA, WHOQOL-BREF were administrated at baseline (before treatment), at2nd weekend after treatment and at6th weekend after treatment.And compared with46cases of healthy people(control group).3. StatisticsAssociation analysis was performed by using SPSS16.0software. Measurement data were shown in the form of mean士standard deviation(x±s)And its comparison were conducted by t-test for independent samples. Enumeration data were shown in the form of rate and its comparisons were conducted by the Way of chi-square test(x2test). Correlation analysis was conducted by Spearman correlation analysis. P<0.05was considered to be significant.Results:(1)The MoCA score in depressive patients before treatment was significantly lower than controls group(P<0.01), there was no statistical difference between the MoCA scores at2nd weekend after treatment and before treatment (P>0.05); At6th weekend after treatment the MoCA score wass significantly higher than that before treatment, but it was significantly lower in the MoCA scores, visual space and executive function, attention, delayed recall compared with normal control group (P<0.01).(2)Patients’s scores about subjective quality of life, subjective health state, physiological field, psychological field, social relations and environmental factors before treatment were significantly lower than healthy controls (P<0.01). At2nd weekend after treatment the scores of subjective health state, physiological area, psychological area, environmental factors were increased than before treatment. After6weeks treatment, the scores of subjective quality of life and subjective health state, physiological field, psychological field, social relations and environmental factors were significantly higher than that before treatment, but still significantly lower than healthy controls.(3) MoCA scores in patients with depression were negatively correlated with HAMD score.(4) Depression patients’ subjective quality of life, the subjective state of health, physiological field, psychological field, social relations, environmental factors were negatively correlated with HAMD score.(5) MoCA scores were positively correlated with subjective quality of life and subjective health, physiological field, psychological field.Conclusion:(1) Cognitive dysfunction exists in depression patients. There was no obvious improvement in cognitive function at the second weekend after treatment by SSRI. At6th weekend after treatment, the cognitive function improved obviously, but the visual space and execution function, attention, and delayed recall had not reached normal levels.(2) depression patient quality of life of a normal population is poor, antidepressant treatment2weekends life quality is improved significantly, the treatment of6weeks life quality level of each factor score were significantly lower than normal controls.(3) The higher the degree of depression is, the more serious cognitive impairment is.(4)The more serious the level of depression was, the worse quality of life.(5) The lighter cognitive dysfunction was, the better the quality of life. |
PDF Full Text Request