Explore The Relationship Between The Expression Of P16, Ki-67and The Thymoma,Including Pathological Types,and Clinical Stage And MG Combine

Objective: To study the expression of P16, Ki-67in thymoma andthymuc hyperplasia. Our aim is about to explore the relationship between theexpression of P16, Ki-67and the thymoma status, including the developmentof thymoma, pathological types, and clinical stage and MG combine.Methods: Using immunohistochemistry SP method to detect theexpression of P16and Ki-67in78cases of thymoma (benign thymoma33cases, malignant thymoma28cases, thymic carcinoma17cases)and thymushyperplasia14cases,through amicroscope to detect the positive and negativeexpression. All the result were stastistically analyzed with SPSS17.0softwarepackage.Results:1The positive rate of P16in thymus hyperplasia, benign thymoma,malignant thymoma and thymic carcinoma were85.7%,75.8%,60.7%,29.4%,it showed a trend of gradually decreased with the development of pathologicaltype,and the difference among the four types was significant. There were sign-ificant differences about the expression of P16in thymus hyperplasia andthymic carcinoma, thymoma and thymic carcinoma(P<0.05),but there was nodifference among thymus hyperplasia and thymoma, benign thymoma andmalignant thymoma(P>0.05). The positive rates of p16was graduallydecreased in Masaoka clinical stage Ⅰ, Ⅱ, Ⅲ, Ⅳ were79.2%,70.0%,52.4%,23.1%. There were significant difference among the Masaoka Ⅰ,MasaokaⅢ, and Masaoka Ⅳ(P<0.05),but the others have no significantdifferences. The positive rates of P16were57.4%in tissues of thymomawith MG,and64.5%without MG, there were no difference between the twogroups (P>0.05). 2The positive rate of Ki-67in thymus hyperplasia, benign thymoma,malignant thymoma and thymic carcinoma were78.6%,30.3%,53.6%,88.2%,and the difference between the thymoma and thymic carcinoma. Wassignificant(P<0.05). The positive rates of Ki-67was gradually decreased inMasaoka clinical stage Ⅰ, Ⅱ, Ⅲ, Ⅳ were8.3%,45.0%,81.0%,92.3%,and thedifference among the each types was significant(P<0.05),except MasaokaⅢand Ⅳ(P>0.05). The positive rates of Ki-67were57.4%in tissues of thymomawith MG,and64.5%without MG, there were no difference between the twogroups (P>0.05).Conclusion:1The expression of P16protein has certain correlation with pathological typesof thymoma,but not with invasion. It may play a certain anticancer effect inthe early stages of thymic tumor and cancer.We must do some further researchto prove that whether it can be helpful in the diagnosis of invasive thymoma.2The expression of Ki-67has close relationship with pathological types andMasaoka clinical stage.The Ki-67not only will be helpful in judging themaligant degree,but also in providing important reference for the diagnosis ofthymoma.3The expression of P16and Ki-67play a role in the occurrence anddevelopment of thymoma. Unite examining the P16and Ki-67will be helpfulto comprehensive evaluation and to guide treatment.