Effects Of Atorvastatin On Plasma Tnterleukin-1β、Interleukin-6and Tumor Necrosis Factor-α In Patients With Acute Cerebral Infarction

Objective:Through study atorvastain in treatment of ischemic stroke and observe thelevels of serum IL-1β, IL-6, TNF-αprotein and the neurologicalfunction on different phases, explore the intervention effect of statinson the mechanism of acute cerebral infarction inflammatory injury. Toprovide valuable evidence for standard therapy for patients with acutecerebral infarction early on the use of statins.Methods:(1)60patients with acute cerebral infarction, randomly divided intoroutine group and treatment group by the patient’s treatment sequence.30healthy cases as the normal control group.(2) Routine group: the conventional treatment including resistingplatelet aggregation (aspirin0.1qn), brain protecting agent andimproving brain circulation. Treatment group: adding atorvastatin(atorvastatin20mg qn) to the conventional treatment.Vein blood samplecollected before breakfast on the morning before therapy and the firstweek, the second week after therapy. IL-1β, IL-6, TNF-αwere testedby ELISA. At the same time, the normal samples were collected once.(3) The neurological function for all subject were evaluated by the U.S.National Institutes of Health Stroke amount (NIHSS) and daily livingscale Barthel index(BI)score before and after therapy. Results:1. Compare routine group with treatment group. The gender composition,average age, the NIHSS score and the levels of serum IL-1β, IL-6, TNF-α have no significant differences (P>0.05).2. Before treatment, the levels of serum IL-1β, IL-6, TNF-α in thetwo experimental groups is higher than the normal control group(P <0.01).3.(1) After one week, compared with the untreated, the level of serumIL-1β, IL-6and TNF-αdecreased significantly (P <0.05), while thetreatment group decreased more significantly (P <0.05).(2) After twoweeks, the levels decreased significantly than before therapy (P <0.05),and the treatment group decreased more significantly than the normalcontrol group (P <0.05).(3) After two weeks of treatment, the score ofNIHSS is lower than before treatment, in the two experimental groups (P<0.05), the treatment group decreased significantly than the normalcontrol group (P＜0.05).Conclusion: With astorvastain treatment of acute cerebral infarction,the level of serum IL-1β, IL-6and TNF-α will be decreasedsignificantly and the neurological function will be improved.