Gliclazide Sustained Release Microsphere Preparation Technology Research

The subject prepares drug particles by using different methods, different polymericmaterials as a model drug of gliclazide. The drug gliclazide microsphere is prepared bythe dropping method, and chitosan and alginate being used as block material. What’smore, the gliclazide sustained release microcapsule is prepared by using ethyl celluloseas capsule material and drying in liquid method.The vitro essay shows that the gliclazide maximum absorption wavelength is228nm and it determinates drug solubility and stability in different media by. UV scans. Atthe same time, it established initially the release and the determination method forcontent of gliclazide sustained release particles. It also investigates that the recoveries ofthree kinds of polymer materials of gliclazide sustained release particles are in line withrequiements. And the content of gliclazide sustained release tablets is determinated byHPLC.Based on single-factor test and L9(34)orthogonal experiment design, the optimalpreparation technology of sodium alginate microspheres of gliclazide is prepared bydripping method: the concentration of sodium alginate2.00%, the concentration ofCaCl20.60%, sodium alginate and drug in the ratio of6:1, the size of microsphere0.50mm. The drug release process of calcium alginate gliclazide sustained releasemicrospheres in vitro can be described by model of Ritger-Peppas linear equation:Y=-0.9009x+2.4649(R=0.9930). During the entire drug release seen in the precedingdrug release process belongs to the frame erosion mechanism, after the drug releaseprocess for Fickian diffusion mechanism.Based on single-factor test and L9(34)orthogonal experiment design, the optimalpreparation technology of alginate/chitosan microspheres of gliclazide is prepared bydropping method: the concentration of chitosan0.40%, and the action time of chitosanand alginate2h and pH of chitosan5.5and the molecular weight of chitosan3w and the size of microsphere0.50mm. The drug release process in vitro can be described bymodel of Ritger-Peppas linear equation: Y=-1.0490x+2.9150(R=0.9896). Seen in theentire drug release process, first section is to spread and matrix erosion dual mechanismof release, middle section to matrix erosion mechanism, finally to Fick proliferation.Based on single-factor test and L9(34)orthogonal experiment design, the optimalpreparation technology of the gliclazide ethyl cellulose microcapsule is prepared bydrying in liquid method: stirring speed100r/min, volatile temperature of48°C,ethyl-cellulose was used as wall material, with gliclazide in drug quality ratio of3:1, thequality of the emulsifier0.15g, the amount of ethylene chloride7.00g. The preparationof the appearance is white, with the average arithmetic granularity diameter is1.00μm.The drug release process in vitro can be used to fit the Higuchi equation:Q=4.7597t1/2-26.435(R=0.9911). The drug release process is initially to matrix erosionmechanism, and intermediate is spreading and matrix erosion dual mechanism of release,finally to Fick of diffusion drug release from mainly.Cumulative release as the reference standard, the three different polymer blockmaterial of gliclazide sustained release particles compared to commercial gliclazidesustained-release tablets, the results showed that it accord with the marketed gliclazidesustained release tablets in the dissolution time. The technology is simple. Thepreparation method and technology can be extended to similar insoluble drugmicro-encapsulation process, having good application prospects!...