| ObjectiveTo study the characteristics of Traditional Chinese Medicine (TCM) clinic presentations in amnestic mild cognitive impairment, and the correlation between TCM clinic presentations and cognitive level, to provide evidence for early diagnosis and TCM treatment of senile Alzheimer’s Disease.MethodsThere were some patients from DongZhimen hospital and some volunteer who were recruited from many communities between March2011and January2012. We used various of neuropsychology scales, including Mini-Mental State Examination (MMSE), Clock Drawing Test (CDT), Instant Story Recall (ISR), Delayed Story Recall (DSR), Ability of Daily Living (ADL), Clinical Dementia Rating(CDR), Hamilton Depression Scale(HAMD), Hachinski Ischemic Score to assess the subjects’cognitive functions. And then make a diagnosis of TCM clinic presentations according to the information we got by inspection, auscultation-olfaction, inquisition palpation and pulse-feeling. The subjects fitting to the criteria of study were divided into three groups:NC group, aMCI group, AD group. The study included377subjects,199cases in the NC group,74in the aMCI group, and106in the AD group.Use the case control to compare the subjects of three groups. The emphasis was to analyze the characteristics and the distribution regularity of TCM clinic presentations, and study the correlation between TCM clinic presentations and cognitive level in aMCI and AD group.Results1. The average of age of the AD group was higher than the aMCI group (p=0.029) and the NC group. There was significantly difference on educational level between three group (p=0.017). The educational level of the NC group was higher than the aMCI group (p=0.000) and AD group (p=0.000), but the level of the aMCI group and AD group wasn’t significantly different (p>0.05).2. Scores of syndrome of brain confused by phlegm in the aMCI and AD group were significantly higher than that of the NC group (p=0.033, p=0.025), and the scores of syndrome of blood stasis in brain in the aMCI group and AD group were significantly higher than that of the NC group (p=0.046, p=0.045), but there were no any significantly difference on the score of all syndrome in the aMCI and, AD group. The frequencies of syndromes of brain confused by phlegm in the aMCI and AD group were both significantly than that of the NC group (p=0.000, p=0.000), and the frequencies of syndrome of blood stasis in brain in the aMCI group and AD group were significantly higher than that of the NC group (p=0.010, p=0.015), but there were no significant ly difference on the frequencies of any syndrome of TCM in the aMCI group and AD group (p>0.05). By the Logistic analysis,we know there were significantly correlation between the syndrome of brain confused by phlegm and the appearance of aMCI and AD (p=0.000, p=0.000), the partial correlation coefficients were0.246and0.270.3. By partial correlation analysis, we know there was a negative correlation between the score of MMSE and the score of syndrome of brain confused by phlegm (R=-0.566, p=0.024)in the group of aMCI and AD, as well as between the score of MMSE and the score of syndrome of viscera stagnation and turbid left (R=-0.287, p=0.036) in the AD group,as well as the score of IWR and visual spatial ability with syndrome of viscera stagnation and turbid left (p=0.036, p=0.038).Conclusion1. The educational level and age are the risk factors of the aMCI and AD group;2. The primary characteristics of TCM syndrome of aMCI and AD are brain confused phlegm, blood stasis in brain, and deficiency of kidney essence, the frequencies and severity of brain confused phlegm and blood stasis in brain are all significantly higher than de normall cognitive people. The syndrome of brain confused by phlegm is the risk factors of the aMCI and AD group;3. The syndrome of brain confused by phlegm and blood stasis in brain are the primary TCM syndromes which are influence the AD patients’cognitive function. The time orientation ability of the AD patients who have the syndrome of brain confused by phlegm is lower than those who don’t have one. The memory and visual spatial ability of AD patients who have the syndrome of blood stasis in brain are all worse than those who don’t have one. |
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