Mild Cognitive Impairment And Cognitive Syndromes Correlation Factors

Objective:To explore characteristics of Traditional Chinese Medicine (TCM) clinic presentations in amnestic mild cognitive impairment (aMCI), and the correlation between the cognitive functions and TCM clinic presentations, to provide evidence for differentiation of syndromes and treatments in Chinese Medicine.Methods:The cognitive functions of199persons from Dongzhimen Hospital and some volunteers who were recruited from many communities between March2012and December2013. We were using Chinese version of Mini-Mental State Examination (MMSE), Clock Drawing Test (CDT), Ability of Daily Living (ADL), Clinical Dementia Rating (CDR), Hamilton Depression Scale (HAMD) to evaluate their cognitive level, and then divided them into aMCI, normal cognitive (NC) and Alzheimer’s disease (AD) groups. All groups were scored referring to the pattern element scale in dementia patients (AD-PES-11). The emphasis was to analyze the characteristics and the distribution regularity of TCM clinic presentations, and study the correlation between TCM clinic presentations and cognitive level in aMCI.Results:(1) The average age of the AD group was higher than the aMCI group (p=0.000)and the NC group(p=0.000).There was significantly difference on educational level between three groups.The educational level of the NC group was higher than the aMCI group p=0.010) and AD group (p=0.000), and the level of the aMCI group is higher than AD group(p=0.010).(2) Scores of element of Kidney deficiency in the aMCI and AD group were significantly higher than that of the NC group (p=0.012, p=0.050). Scores of element of Marrow deficiency in the aMCI group and AD group were significantly higher than that of the NC group (p=0.043, p=0.000), and the scores of element of Marrow deficiency in AD group were significantly higher than that of the aMCI group (p=0.000). Scores of element of Blood stasis in AD group were significantly higher than that of the aMCI and NC group (p=0.035, p=0.001). Scores of element of Phlegm muddiness in AD group were significantly higher than that of the aMCI and NC group (p=0.017, p=0.001). Scores of element of Blood deficiency in the aMCI were significantly higher than that of the NC group (p=0.016).(3) The frequencies of element of Kidney deficiency in the aMCI and AD group were both-significantly higher than the NC group (p=0.006, p=0.003). The frequencies of element of blood stasis in the aMCI group and AD group were significantly higher than the NC group (p=0.006, p=0.001). The frequency of element of Marrow deficiency in AD group was significantly than the aMCI and NC group (p=0.009, p=0.000). The frequency of element of Phlegm muddiness in AD group was significantly higher than the aMCI and NC group (p=0.037,p=0.009).(4) The negative correlations in aMCI group contained the scores of element of Phlegm muddiness and the scoresof Immediate word recall (p=0.050); the scoresof element of Blood stasis and the scores of delayed word recall (p=0.020); the scoresof element of Blood deficiency and the scores of calculation (p=0.025); the scores of element of Marrow deficiency and the scores of language function (p=0.045). By partial correlation analysis, we know there was a negative correlation between the score of calculation and the score of Blood deficiency,Marrow deficiency(p=0.017, p=0.024).Conclusion:(1) The educational level and age are the risk factors of the aMCI and AD groups;(2) The primary characteristics of TCM syndrome of aMCI are Kidney deficiency, Phlegm muddiness, Blood stasis and Qi deficiency. The frequencies of Kidney deficiency and blood stasis are all significantly higher than normal cognitive people. The elements of Phlegm muddiness and blood defficiency are both the risk factors of the aMCI group;(3) The syndrome of Phlegm muddiness, Blood stasis and Blood defficiency are the primary TCM syndromes which are influence the aMCI patients cognitive function.