Settlement Separation Method Of Clinical Research For The Treatment Of Chronic Glomerulonephritis

Chronic glomerulonephi tis (CGN) is a kind of common disease in the Department of Nephrology and have the highest incidence in the various kinds of kidney in China.It led to the most common cause of end-stage renal disease (ESRD). Pathological development of chronic nephitis experience the continuous deposition of extracellular matrix in the kidney, conplete nephron reduction and glomerular filtration rate decreased and uiltmately the formation of the pathophysiological process of renal fibrosis (renal failure). Excessive extra-cellular matix (ECM) accumulation was considered to only pathological changes from chronic nephritis to end-stage renal disease. This process is consistent with the formation and development of shenluozhengjia. The theory not only explain the pathophysiological changes, but have a preliminary study in the relationship between pathological changes of the nephropathy and the etiology, pathogenesis in TCM. We proposed hejiejusan formula to study the clinical significance of the prevention of chronic nephritis progress to ESRD, which is under the guidance of pathogenesis of shenluozhengjia theory.The thesis divided into two parts:literature review and clinical study.The first part is the literature study including two papes.The first one was about the research progress of Pathogenesis of CGN. It was stated combined with several years of research in TCM from the point of view of its proteinuria hematuria edama in TCM. The second one states the discussion of shenluozhengjia theory, that it is a brief discourse about the etiology and pathogenesis of kidney based on pathogenesis and pathological changes of the Nephritis. The hejiejusan formula was briefly discussed.The second part is clinical study. Objective:In the clinical study, we verify the correctness efficacy and safety of the treatment of CGN. Methods: We selected68patients of CGN, and divided them into groups randomly and comparably,38cases were in treatment group,30in control group. Both of groups were treated by Chinese herb. The control group was just treated by nephritis rehabilitation tablets. We observed the urine protein in24hours, red blood cells of Urine Sediment, scores of Chinese medicine symptom and curative effect after two months. Results:In treatment group, the urine protein in24hours decreased very shapely (P<0.01), while in control group, it also deceased sharply (P<0.05). However, the effect is much better in treatment group. Red blood cell of urinary sediment had significant deviation comparing before treatment in the treat group (P<0.05). After the treatment, compared with the control group, the red blood cell of urinary sediment was significantly decreased (P<0.05). After treatment in two groups, serum creatinine and blood urea nitrogen has no significant decrease. The syndroms total score about clinical symptoms and signs was significantly decreased, but the effect of improving symptom of treatment is better than the control group. The effective rate of is84.2%in treatment, while it is53.4%in control group.Conclusion:It suggests that hejiejusan method is safe and effective in treatment of chronic nephritis and preliminarily confirms shenluozhengjia theory has higher theoretical significance and clinical studyin inclinical efficacy. The hejiequsan formula can improve the clinical symptoms of chronic nephritis, signs and reduce proteinuria and may slow down the progession of chronic nephritis.