| 1PurposeClinical study based on the previous basic and clinical trials, to select non-small cell lung cancer Ⅲ b, Ⅳ patients for the study observed drugs already on the market capsules of green tea polyphenols, randomized, controlled observation, focused observation tea polyphenol capsule with the observation of the clinical efficacy of chemotherapy in advanced non-small cell lung cancer, at the same time, clinical symptoms and patient quality of life evaluation, combined wi th before and after treatment of tumor markers (CEA, Cyfra211, CA125), tumor neovascularization factor (VEGF, bFGF, and TIMP-2) expression levels of determination, determination of immune function, studies of green tea polyphenols capsule combined with chemotherapy in advanced non-small cell lung cancer clinical efficacy, and inhibition of lung cancer angiogenesis mechanisms preliminary exploration study.2MethodsCollected61cases of effective NSCLC cases, simple random randomized trial,31patients in the control group of30cases.61cases underwent conventional chemotherapy, the experimental group in addition to chemotherapy in the chemotherapy cycle to give oral tea polyphenol capsules,2times a day, every2. After two cycles of chemotherapy efficacy evaluation, indicators, including tumor size of tumor, KPS score, clinical symptoms score, tumor markers, immune function, angiogenesis factors and other indicators.3Conclusions①tumor response assessment:the test group, the total response rate (CR+PR+SD)80%of the control group response rate (CR+PR+SD)73%(P>0.05), the difference was not statistically significant.②The TCM symptom score: the test group after the treatment of TCM symptom score averaged10.36points, control group average of14.76points higher than the experimental group (P<0.05) difference was statistically significant, indicating that polyphenols can improve chemotherapy clinical symptoms of patients with Chinese medicine.③KPS score: the experimental group after treatment KPS mean score of81.39, to control the average score of the group KPS KPS score of73.47, after treatment, the experimental group and control group was statistically significant (P<0.05), indicating that polyphenols can relieve the tumor during chemotherapy decline in KPS score, and improve patients’quality of life.④immune function: the control group were Foxp3and CD4/CD8changes were not statistically significant (P>0.05); changes in the value of the experimental group before and after treatment of Foxp3was no significant (P>0.05), while the CD4+/CD8+changes statistically s ignif icant (P<0.05), suggest ing that the polyphenols capsule with adjustment of the immunosuppressive state.⑤The tumor markers:After treatment, the tumor marker changes were not statistically significant(P>0.05).4ResultsThe polyphenols capsule combined with chemotherapy can improve the symptoms of advanced non-small cell lung cancer patients during chemotherapy Chinese medicine to relieve the decline of the patients during chemotherapy, KPS, and improve patients’quality of life, and have to adjust the immunosuppressive role of the state. |
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