The Related Factors Influencing The Left Ventricular Diastolic Function Analysis

[Objective]To explore the relationship between heart rate variability (HRV) and left ventricular diastolic function in middle-aged individuals.[Methods]One hundred and thirty eight subjects in a random sample aged30to60years without apparent heart disease were recruited. A standardized questionnaire was used to collect information on medical history, smoking, alcohol intake and use of medications. Blood pressure was measured by mercury sphygmomanometer. N-terminal pro-brain natriuretic peptide (NT-proBNP) was measured in plasma by enzyme-linked immunosorbent assay. Color Doppler ultrasound was used to measure indicators of left ventricular diastolic function and structure. Resting diastolic function was graded as normal diastolic function (n=74), impaired relaxation (n=36), pseudonormal (n=28). Heart rate variability on time-domain and frequency domain indexes was monitored by24-hour ambulatory electrocardiogram.[Results]1. With advanced degree of diastolic dysfunction, logNT-proBNP increased(1.8±0.2;1.9±0.2;2.0±0.2pg/ml,P<0.01)and LF decreased(21.0±5.2;18.5±5.4;17.8±6.3ms2, P<0.05) significantly.2. Adjusted for age, sex, heart rate and medication, rMSSD, pNN50%and HF were inversely correlated with peak A (r=-0.210,r=-0.194,r=-0.212,P<0.05),and positively correlated with E/A (r=0.189,r=0.189,r=0.175,P<0.05); VLF and LF were positively correlated with EDT (r=0.265,r=0.194,P<0.05), inversely correlated E/E’(r=-0.174,r=-0.173,P<0.05) and logNT-proBNP (r=-0.315,r=-0.345, P<0.01).3. Multivariate stepwise linear regression showed that peak A was an influence factor of pNN50%(β=-0.200,P=0.012), E/E’ and logNT-proBNP were risk factors of LF (β=-0.178,P=0.023;β=-0.165,P=0.019), while E/E’ and EDT were risk factors of VLF (β=-0.170,P=0.021;β=0.177,P=0.015).[Conclusions]In middle aged individuals, left ventricular diastolic dysfunction was impossibly associated with autonomic nervous dysfunction. [Objective]To explore the association between growth differentiation factor-15(GDF-15) and arterial stiffness and left ventricular diastolic function in middle-aged individuals.[Methods]With a random sample,178individuals aged30to60years without apparent heart disease were recruited. A standardized questionnaire was used to collect information on medical history, smoking, alcohol intake and use of medications. Blood pressure was measured by mercury sphygmomanometer. GDF-15was measured in plasma by enzyme-linked immunosorbent assay. Color Doppler ultrasound was used to measure indicators of left ventricular diastolic function and structure. Brachial ankle pulse wave velocity (baPWV) was determined by the full-automatic arteriosclerosis diagnostic instrument.[Results]1. With advanced levels of GDF-15, E/A and E’decreased(P<0.05), while E/E’ and baPWV increased significantly (P<0.05)2. Adjusted for age and sex, baPWV was inversely correlated with E’(P<0.05), and positively correlated with E/E’(P<0.01), subdivided each study group by tertiles of GDF-15, the same result was found (P<0.05)3. Multivariate stepwise linear regression showed that logGDF-15and age were both influence factors of baPWV,E’and E/E’(P<0.01)[Conclusions] GDF-15was an independent risk factor for arterial stiffness and left ventricular diastolic dysfunction, which may lead to the deterioration of both arterial stiffness and LV diastolic dyfunction in middle aged individuals.