| Primary nephrotic syndrom (PNS) belongs to categories such as Shui-zhong, Yin-shui, Shen-feng Guan-ge etc. Nowadays, curing of PNS mostly uses adrenal corticosteroid, cytotoxic drug, Ciclosporin A etc. Among them, adrenal corticosteroid is the main medicine of PNS. Although useful in curing, but can demage body’s normal function of immunity, develope dependance to negative reaction of adrenal corticosteriod, furthermore can repeat the disease. It is particularly important to provide a theoretical basis for a better play to the advantages of Chinese medicine in the treatment of PNS based on the traditional Chinese medicine theory and the experience of predecessors.This research, based of criteria of screening, has been collecting for30years,122medical records of the traditional Chinese medicine treatment of PNS and researched their prescription drug law. First, we arranged the medical cases which meet the inclusion criteria and established a database by using Epidata version3database software in Windows XP platform. Then, through statistical software SPSS17.0, we analyzed the whole225herbs from different ways, such as the nature of the drugs and the frequency statistics. At last, we used Complex System Entropy Method to analysis of relevance between the drug and obtained most interrelated single herb and key herb pairsAs shown in statistics result, a treatment of PNS mostly uses tonic and meanwhile, combined with medicinal herbs which have functions of eliminating dampness and diuresis, promoting blood circulation for removing blood stasis, cooling blood for hemostasis. clearing heat-toxin, clearing heat-toxin, dispelling wind to resolve exterior, astringing. Those key herbs include: Atractylodes. Astragalus. Licorice root, Chinese yam, Poria, Alisma, Dogwood, etc.The core couplet medicines include:Atractylodes-Poria. Atractylodes-Astragalus, Porin-Chinese yam, Atractylodes-Alismn and so on. Atractylodes. Astragalus and Motherwort have the strongest correlation. After passing a complex entropy-gathered method, the final37key couplet medicines are obtained. Based statistical analysis, summarize the characteristics and the rules of formulas of30-year-old the traditional Chinese medicine treatment of PNS:1. The causes of PNS are multitudinously, the pathogenesis are complicated, the clinical manifestation are differently and the treatment method are variously. Nevertheless, the treatment aiming at disease’s pathogenesis, on account of deficiency of the genuine and excess of the evil. In clinic, the treatment and herbal prescription based on syndrome differentiation will achieve better effects.2. Mainly used toxic prescriptions, trend to the medicine invigorating qi, especially tonifying the spleen, lung and kidney; supplementary the method of eliminate dampness and diuresis to relieve edema. Promote blood circulation, in order to alleviate the hematuria because of stasis of blood. The purpose of giving consideration to keep body warm, to warm spleen and kidney. Just as take measures to prevent diseases from occur. Meanwhile, tonifying the liver and kidney to control seminal emission. Treating both the "branch" and the "root" simultaneously.3. According to the results of statistics, abstract the couplet medicines, drugregimen and treatment which are in common usage.4. Based on PNS’ characteristic and the particular of its factor, choosing drug regimen which suit to use in clinic. In expectation of comprehensive judgment from experts and combine with clinical trial, establish candidate of R&D of new Chinese herbal medicine for PNS treatment. |
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