Phlegm And Dispelling Stasis Method For The Treatment Of Obstructive Sleep Apnea Hypopnea Syndrom Preliminary Efficacy Evaluation

Obstructive sleep apnea-hypopnea syndrome (OSAHS) with cardio-cerebral vascular diseases and multiple organ injuries, seriously endanger the health of people, is the only began to be concerned about the frequently occurring illnesses in recent years. Ventilator is the best treatment of OSAHS which lack of effective drugs at present. Traditional Chinese medicine on the disease and no medicine, but in recent years, the Chinese medicine practitioners continue to explore and on the etiology and pathogenesis of the disease, differential treatment has a certain degree of understanding, and have achieved certain effects, but due to many factors, its efficacy has not been widely recognized.This article includes literature reviews and clinical trial in two parts.Literature review summary basis sleep respiratory diseases of the respiratory diseases branch of Chinese medical association established by the Group of the diagnosis and treatment of obstructive sleep apnea-hypopnea syndrome Guide, combined with Western medicine study on the disease in recent years, OSAHS from definition, etiology, pathogenesis and path physiology, diagnosis and treatment of disease indexing and do a more detailed introduction. Literature review according to the second Chinese medicine awareness of ancient and modern Chinese medical literature on the disease, including Chinese ancient awareness of this disease, pathogenesis, syndrome differentiation and treatment study.clinical trialObjects:To Preliminary evaluate the clinical efficacy and safety of the method of removing blood stasis and reducing phlegm for obstructive sleep apnea hypoventilation syndrome(OSAHS), and to explore the evidence-based medicine basis of moving blood stasis and reducing phlegm in TCM for obstructive sleep apnea hypoventilation syndrome(OSAHS).Methods:240patients were chosen with phlegm and blood stasis syndrome, in light and moderate ranges. Sanbeizhuhan capsules of TCM prescription of removing blood stasis and reducing phlegm were applied as clinical intervention, with multicentre, randomized block, double-blind, placebo-controlled and superiority trial. Compare the clinical efficacy before and after the treatment, TCM symptom scores, sleep apnea-hypopnea index, minimum night peripheral oxygen saturation and other indicators.Result:We collected203qualified cases and37defluxion cases. In treatment group,5cases were cured,64cases had significant effect,4cases had effective effect,27cases had non effect. In the control group,4cases were cured,22cases had significant effect,14cases had effective effect,63cases had non effect. The results had statistically difference, with P=0.0267<0.05.Conclusion:Sanbeizhuhan capsules of the prescriptive of removing blood stasis and reducing phlegm can significantly reduce the AHI index of OSAHS patients with phlegm and blood stasis syndrome and improve the lowest nocturnal oxygen saturation SaO2. In the curative effect judgment of TCM symptoms, the overall condition of the patients significantly improved after treatment, with the improvement of the life quality. It is safe to take Sanbeizhuhan capsule, with no toxic and side effects, and it is well tolerated. We can expand the range of clinical use, to further demonstrate the effectiveness.