Ziyin Drop Stomach Soup Treatment Of Diabetic Gastroparesis Clinical Observation

Objective:Based on the clinical practice found that ziyinjiangweitang regulated gastric motility significantly, in a randomized, controlled study methods, use EndoFLIPs observe ziyinjiangweitang and domperidone in patients with diabetic gastroparesis on change gastrointestinal motility and clinical symptom score, the total effect, test indicators improved. To reveal the ziyinjiangweitang "jiangweixiaopi" on regulation of gastric motility in patients with diabetic gastroparesis provide clinical evidence to prove "jiangweixiaopi" treatment of diabetic gastroparesis effectiveness, feasibility and Medicine therapeutic advantage.Methods:Meet the diagnostic criteria for diabetic gastroparesis and inclusion criteria,60patients were randomly assigned into treatment group and control group,30cases in each. Two weeks before entering the study subjects, which began a strict diet, the amount of movement required, one week before the test does not use any newly added gastrointestinal motility drugs. Those who have not use western medicine, they are not with substandard medicine in the experiment. Drugs to control blood sugar continues to use the original program. Treatment group use ziyinjiangweitang,fasting, before going to bed each time, once a bag (200mill iliter), control group to domperidone tablets,10milligram, three times a day.30days after treatment, general information on two groups of patients, respectively, from gender, age, duration, fasting blood-glucose.2hplasmaglucose, haemoglobin Ale aspects of the pre-treatment baseline, no significant difference. Design TCM clinical symptom score table, evaluate cross-sectional area at the bottom of the esophagus in patients, detection of patients with the blood, urinary and stool routine test, hepatic and renal function,ECG changes, the patients were followed for six months. According to traditional Chinese medicine treatment of patients with clinical symptoms before and after integration, the total effect compared to the bottom of the esophagus cross-sectional area (30,40milliliter balloon volume). Six months after the relapse rate and blood, urinary and stool routine test, liver and kidney function, ECG, etc. To evaluate ziyinjiangwei tang treatment of diabetic gastroparesis stomach efficacy and adverse reactions and side effects. Results:30days after treatment:1. clinical symptom scores:the treatment group is more satisfactory improvement than the control group in the clinical symptoms (P<0.01), there was significant difference, indicating the efficacy of ziyinjiangweitang excellent than domperidone.2, the cross-sectional area at the bottom of the esophagus (30,40ml balloon volume):cross-sectional area at the bottom of the esophagus treated group than the control group decreased. Comparison of two groups had significant difference (P<0.01). The treatment group improved more than the control group of diabetic gastroparesis gastric emptying rate.3, the total effect before and after treatment:the treatment group was significantly better than the control group (P<0.05), the resul ts are statistically signi ficant.4,6months after the relapse rate compared two groups of treatment and control group, was significantly decreased (P<0.01), the recurrence rate between the two groups had significant differences.5, two groups of patients were examined before and after treatment of blood, urine, feces and liver and kidney function, electrocardiogram, were within the normal range. Course of treatment, both groups of patients no adverse reactions.Conclusion:1,Zi yinjiangweitang in improving clinical symptoms, reduce the cross-sectional area at the bottom of the esophagus (30,40ml balloon volume), to reduce the recurrence rate after six months have a good effect, better than that of control group,domperidone tablets.2,Ziyinj iangwei tang good safety.3,Ziyinjiangweitang compliance and better tolerated. This study confirmed that the ziyinjiangweitang can significantly improve symptoms in patients with diabetic gastroparesis, narrow cross-sectional area at the bottom of the esophagus, enhanced stomach smooth muscle contraction capabilities, and long-term recurrence rate is lower than domperidone.More worthy of continued use in clinical observation and through animal experiments, cell experiments to clarify its "jiangweixiaopi" mechanism.