| From the beginning of the twentieth century, scientists had been exploreing self-assembly technology of polymer, and provided the theoretical basis for application of self-assembled micelles in various fields. In recent years, scientists begun to study functionalapplication of self-assembled micelles, for example, the micelles were used in the areas offunctional solid particles emulsifier, drug delivery carrier, nano-reactor and chemical sensingdevices etc. In this article, Firstly, a random acrylate copolymer was prepared, then preparedmicelle and applied it to the particulate emulsifier and molecular imprinted polymer micelleelectrochemical sensor respectively. Specific studies are as follows:The first part: An acrylate copolymer poly（dimethylaminoethyl methacrylate–co-acrylicacid-co-4-methylcoumaryl acrylate）（PDMAACA） was synthesized via free radicalpolymerization, prepared micelles and investigated the performance and morphology of themicellar particles under different conditions, then research the influencing factors（micelleconcentration, the crosslinking time and pH value） of emulsifying properties. The resultsshow that the stability of emulsions increased with the increasing of micelle concentration andcrosslinking time and a strong acid or alkaline （pH>12or<2） micellar solution was conduciveto improving the stability of emulsion.The second part: Novel molecularly imprinted polymeric （MIP） micelles were preparedvia macromolecule self-assembly of a photo-crosslinkable copolymer, combined withmolecular imprinting technique using paracetamol as the template molecule. First, an acrylatecopolymer poly （DMA-co-HEA-co-EHA-co-St） was synthesized via free radicalpolymerization using （dimethy-lamino） ethylmethacrylate （DMA）,2-hydroxy ethylacry-late（HEA）,2-ethylhexyl acrylate （EHA） andstyrene （St）. Further postfunctionalization introduceda cross-linkable acrylate side groups into the polymer to form the photo-crosslinkablecopolymer （PDHES） using isophorone diisocyanate （IPDI） as bridges. The photo-crosslinkable copolymer and paracetamol were dissolved to give copolymer mixed solution.Water as a non-solvent, was added to the mixed solution to induce the self-assemblymicellization of the photo-crosslinkable copolymer, during which the template molecules（paracetamol） was entrapped in the micelles through the interactions between paracetamol andthe copolymer chain. The properties and morphology of MIP micelles were characterized bydynamic light scattering （DLS）, zeta potential and transmission electron microscope （TEM）.The MIP micelle solution prepared was used as a bath solution for electrodeposition. A MIPflm was formed in situ on the electrode surface by electrodeposition of the MIP micelles andthen crosslinked by UV radiation to lock the structure and improve the stability of the flm.Finally the template molecules were removed from the flm by extraction, leading toparacetamol imprinted electrode. The electrochemical performance of the MIP electrode wasevaluated by cyclic voltammetry （CV） and differential pulse stripping voltammetry （DPSV）.The MIP sensor showed good response and selectivity towards paracetamol. In addition, Thelinear range was from1×10-64×10-3mol/L, and the limit of detection was3.3×10-7mol/L.The third part: Molecularly imprinted polymeric （MIP） micelles were prepared viamacromolecule self-assembly of PDHES, combined with molecular imprinting technique using melamine as the template molecule, the best performance of molecularly imprinted filmobtained by research the concentration, pH value, the electrodeposition voltage of MIPmicelles, then molecularly imprinted electrode was prepared and detected melamine usingK3[Fe（CN）6] as a probe. This MIP sensor showed excellent selectivity and response tomelamine. The linear range was from1×10-67×10-5mol/L, and the limit of detection was3×10-7mol/L. |
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