Amidation Catalyzed By Alkali Metal Compounds

As an interdiscipline subject of inorganic chemistry, organic chemistry and coordination chemistry, organometallic chemistry has been rapidly developed in recent decades. Especially, with worldwide demand for environmentally friendly chemical processes and products requires the development of novel and cost-effective approaches to pollution prevention, organometallic catalysis has attracted increasing attention by virtue of atom economy in the field of modern chemistry.In the view of the above research background, some ligands and organometallic compounds were synthesized and applied to catalytic reactions. The main work is outlined as follows:Chapter1. The research background and significance of this thesis are introduced:(1) reactions types and research progress of amidation;(2) research progress in catalytic properties of P-diketiminatometal complexes;(3) reactions of β-diketiminatometal complexes with nonmetal molecules.Chapter2. Lithium tert-butoxide was found to be a highly efficient catalyst for amidation. Under room temperature, the reaction of aromatic amines with aromatic aldehydes catalyzed by lithium tert-butoxide(10mol%) could proceed smoothly in diethyl ether(10mL), giving a series of amides in high yield. The highest yield is up to92.8%.Chapter3. A variety of organolithium complexes on the catalytic effect of amidation were investigated, P-diketiminato lithium exhibits the highest catalytic activity. Furthermore, screening out the best catalyst (Li[(C6H5)N(CH3)CCHC(CH3)N(C6H5)]) by changing the structure of ligands and permuting coordinated metal of β-diketiminato lithium. Under room temperature, the reaction of aniline with benzaldehyde catalyzed by Li[(C6H5)N(CH3)CCHC(CH3)N(C6H5)](10mo1%) could proceed smoothly in diethyl ether (10mL), giving N-phenylbenzamide in high yield. The highest yield is up to90.5%. Chapter4. The reactions of β-diketiminatometal complexes with dioxygen were investigated. A novel lithium cluster compound was obtained and the structure of the cluster compound was characterized by NMR and X-ray single crystal diffraction analysis.