Synthesis Of Isoindoline And Heterocyclic Compounds

Isoquinoline compounds have a wide range of applications in biological activityand organic pigments. Currently, it has been one of the important research directions toaccomplish the synthesis of new isoquinoline compounds, find out the biologicalactivity and pharmacological activity as well as develop the potential application values.In the research, we synthesized the isoquinoline compounds derivatives containingnitrogen and sulfur atoms crown ethers through the photoinduced single electrontransfer reaction method. We study photoinduced intramolecular electron transfersystem by using imides (phthalimide and maleimide) as an electron acceptor as well asthe terminal trimethyl silicon and tributyltin ether chain as electron donors. Theimplementing method was used by photoreaction in methanol. Consequently, we obtainedisoquinoline compounds containing heterocyclic crown ether with nitrogen and sulfur inhigh regioselectivity and high yield.This thesis mainly divided into three chapters: the first chapter summarizes theapplications of isoquinoline compound and describes the mechanism of thephotoinduced single electron transfer reaction; the second and third chapter is aboutexperiment parts. These two chapters introduce the process of the photoreaction and thesynthesis of the photoreaction substrate and give a discussion on the development of thephotoreaction substrate of phthalimide and maleimide photoreaction. And the structuresof all the new compounds were confirmed by1H-NMR and13C-NMR and massspectrum.