The Study Of The Biomimetic Ion Channel That Based On The Polymer Membrane: Preparation And Property

Inspired by the biological nanochannels in nature, diverse artificial biomimeticnanochannels has been fabricated by the nanofabrication technology. Due to the significantnano-dimension of the nanochannel in different membrane materials, it provides a solidplatform to further develop disparate intelligent biomimetic nanofluidic devices. However,the structure and the property of the membrane materials which depended on theirsubstantial have an influence up on the fabrication routines of different nanochannels.Currently, there are mainly four types of membrane materials: polymers, inorganics, bioticmaterials, and the composite materials. In this paper, we summarize the recentdevelopments in fabricating1D biomimetic nanochannels in diverse membrane materials.A simple biomimetic ionic gate has been developed by grafting responsive doublestranded8-17DNAzymes to the conical multi PET nanochannels, which can be reduced bylead (Ⅱ) ions. In the experiment of sensitivity and selectivity, we found that, by using ofPb2+cleave double-stranded structure of the8-17DNAzymes to make the effectivediameter of the nanochannels larger, the biomimetic ion nanochannels were activated, weachieve a gate mechanism to bionic ion channels of Pb2+in a concentration range. Theresults show that the after adding lead ions, which is induced by the cleaving of8-17DNAzymes, making an increase of the effective channel diameter. As the intelligentresponse DNAzymes were combined with the nanochannels, this work offers a newresearch platform for more complicated biomimetic intelligent system.Based on the symmetric cigar-shape single nanochannel on PC membrane, weprepared a biomimetic rectified system using ion sputtering of Pt and plasma modificationof PAA, achieve the preparation of proton-control bionic intelligent ion channels. The PAAcan adopt different quantities of charges depending on the pH, so the biomimetic ionchannel could be endowed pH responsive property under the effect of different pH. Thiswork provides a basic platform to obtain rectifications in symmetric nanochannels.