Fabrication Of Nanochannels And Their Application In Transportation

The rapid development of nanotechnology provides a new,reliable and efficient research platform for current life science.Inspired by biological nanochannels,artificial intelligence solid-state nanochannel materials with basic research value and application prospects have been developed in combination with many disciplines and technologies such as nanotechnology,interface chemistry,molecular biology and physical chemistry.Compared to living body ion channels,biomimetic artificial nanochannels materials have more stable properties suitable for in vitro manipulation.In addition,the controllability of their shape and surface chemistry gives them important applications in the fields of sensing,analysis and drug release.In this paper,we fabricated different shape of the nanoschannels based on multiple channels polyethylene terephthalate?PET?films subjected to heavy ion bombardment.Then the response molecules with different functions are modified onto the inner wall of the pore channel to realize the specific recognition and selective transportation of ions or molecules and achieve a stimulus-responsive switch gating system.The main contents are as follows:1.Funnel-shaped nanochannels were prepared by a two-step etching method and the inner surface of the channels were modified with 4'-aminobenzo-18-crown-6 ether molecule?4-AB18C6?.The 4-AB18C6 molecules could combine with K+ions,even at concentrations as low as 10^-15 M,to change the surface charge and wettability of the channel and then regulate transmembrane ionic currents.Meanwhile,the release of K+ions can be realized by applying an external constant voltage.In this way,the switchability between the open state and closed state can be easily obtained.The gating is similar to the protein voltage-gated potassium channel and exhibits excellent stability compared to biological nanochannel,which has potential applications in the fields of controlled drug release and biosensors.2.We report a nano-gating system for on demand molecule transport based on a peptide-gated nanoporous membrane.The conformation transition of peptides from random structure to folded structure was the basis for their gatekeeping capability,and was a fully spontaneous oxidation process,which could be realized in micro-aerobic conditions of aqueous solution.Meanwhile,reversible conformational conversion from folded structure to random structure can be triggered by dithiothreitol?DTT?.Acting as gatekeeper,the peptides introduced to the nanoporous membrane provide an opportunity to realize on-demand on-off states via reversible conformational switching of the peptides.This nano-gating system offers sustained release and can be used as a sophisticated molecule transport platform for localized drug delivery with a feedback function.3.Magnetically responsive nanochannels were fabricated by introduced ferromagnetic nanoparticles.Magnetic actuation provides unique capabilities as it can be spatially and temporally controlled,and can additionally be operated externally to the system,providing a non-invasive approach to remote control.The magnetic response complex PDA-Fe3O4 on the inner surface of the channel moves toward the tip side of the channel under the applied magnetic field,so that the pore diameter decreases.The system has the ability to transport molecules triggered by an external magnetic field,it exhibits excellent stability and controllability,which may be used in response to sensing devices.