Study On The Synthesis Of Sulfide By Copper Power Catalyzed C-S Coupling Reaction

Sulfur-containing compounds are important molecules in organic synthesis and drug synthesis. C-S containing blocks were widely applied in industry production. Sulfides are widely employed in pharmaceutical, polymer materials, pesticides, and perfume synthesis as intermediates. Benzothiazole derivatives have extensive used in pesticides, pharmaceuticals, optical materials and rubber industry. Construction of C-S bonds is an important research field, which has a wide application. C-S coupling reaction has significance in synthesis of sulfide and benzothiazole derivatives. C-S coupling reactions are usually catalyzed by transition metals. There have much research about C-S coupling reaction being reported.In this work, we were explored copper power catalyzed C-S coupling reaction.The thesis includes three chapters.Chapter one:The progress of C-S coupling reaction in sulfide and benzothiazole derivatives synthesisIn this Chapter, a brief introduction of the C-S coupling reaction in sulfide and benzothiazole derivatives synthesis was given. Different metals such as Pd, Ni, Cu, Co, Fe and In catalyzed C-S coupling reactions and different sulfur sourcees as substrates were described; methods of benzothiazole derivative synthesis has been categorized and presented.Chapter two:Study of copper power catalyzed synthesis of sulfide and benzothiazole derivativesThe synthesis of diaryl sulfides with aryl iodides and thioureas catalyzed by copper powder in the presence of base was explored. Under the optimized conditions seven symmetrical diaryl sulfides are synthesized. Compared with previously reported reaction conditions, the reaction has following advantages:easily available starting material, cheap and stable catalyst, convenient operations, environmentally benign and high yields.Chapter three:Study of one-pot synthesis of trifluoromethyl-contain tetrahydroquinolineThe Friedlander reaction of2-aminobenzaldehyde with ethtrifluoroacetoacetate was proceed in one-pot reaction. Trifluoroacetoacetate as substrate produced quinoline derivatives and tetrahydro-quinoline derivatives generated.