Studies On The Transition Metal-free Synthesis Of Heteroaryl Ether And Heteroaryl Sulfur Ether

The formation of heteroaryl-sulfur bonds and heteroaryl-oxygen bonds have emerged as a powerful means for the synthesis of many molecules that are of biological,pharmaceutical,and materials interest.In this paper,recent advances were reviewed respectively in the synthetic methods for the heteroaryl-sulfur and heteroaryl-oxygen compounds,then it was discussed the study of their synthetic methods.The first part reviewed recent advances in the synthetic methods for heteroaryl ether.The second part studied the transition metal-free C-O cross-coupling reaction of heteroaryl chlorides with alcohols and phenols.The third part reviewed recent advances in the synthetic methods for heteroaryl sulfur ether.The fourth part studied the transition metal-free TBAF catalyzed SNAr reaction of heteroaryl halides with hrimethyl(phenylthio)silane.The fifth part studied the the transition metal-free C-S cross-coupling reaction of heteroaryl chlorides with diphenyl sulfide.The above study synthetic methods of heteroaryl-sulfur and heteroaryl-oxygen compounds enjoy many advantages,such as simple,raw materials readily available,metal-free,high yields.Moreover,this synthetic methods reduce the pollution to the environment,which was fit to the development direction of green chemistry.