Study On Osteoarthritis Of The Knee No.1Patch Prepared

Purpose: The preparation and quality control of the knee joint patch, the experiment carriedout a more detailed study, as well as to determine the compound of the preparation processand quality standards.Method: In this study, the introduction of modern means of extraction, reflux extraction ofalcohol-soluble active ingredient, steam distillation of the volatile components, water theBentiu head alkali studied Chinese herbal compound reasonable extraction, separation andpreparation, the use of scientific and mathematical statisticsapproach, that each step of theorthogonal Design experimental conditions.Result:1.Alcohol soluble active ingredients for optimum extraction conditions: Add anamount of8-fold with80%ethanol, and extracted two times, each for1.5h.2.The optimumextraction conditions of the water-soluble active ingredients: Add10-fold amount of water,each soaking1.5h, extracted two times, each for1.5h.3. Optimum extraction conditions forthe active ingredients of the volatile oil: Volatile Oil collected after herbs added10-foldamount of water to soak for30minutes, extraction1.5h. Set of square patch matrix screeningprocess, Determine the skeleton of the formula matrix material is sodium polyacrylate NP-700,cross-linking agent for the glycinate aluminum, crosslinking regulator tartrate, Adhesives ascarbomer and sodium carboxymethyl cellulose, Moisturizers glycerol, The optimum ratio, thesodium polyacrylate NP-700: glycinate aluminum: tartaric acid: glycerol: carboxymethylcellulose sodium: carbomer=4:0.08:0.16:4:0.2:0.25. The three parts of the medicinal extractthe active ingredient is mixed with the matrix to prepare a patch.Conclusion: The patch in the preparation of success after a series of quality standards, thevarious components of the group prescription has to be extracted, through the choice of theindex components in the content determination, aconitine, curcumin, Qioleanolic acid,eucalyptol, total flavonoids in the Pharmacopoeia check within the. The patch itself earlyAdhesion, holding adhesive power, well endowed. This article will be knee osteoarthritispaste the pharmacological effect of a series of experiments, the prescription without any sideeffects on the human skin, good absorption effect by the Pharmacodynamics hot plate,writhing through acute toxicity irritant experimental found, anticoagulant experiments can draw the patch with obvious blood circulation, anti-inflammatory and analgesic effect, thepatch is safe and reliable, the effect is obvious. New dosage forms of Chinese medicineWestern medicine active ingredient combination, fully illustrated in the traditional Chinesemedicine theory, under the guidance of more efficient formulations prepared by the use ofmodern science and technology is feasible.