Intraocular Lens Modified With MPC Co-polymer And Its Biocompatibility

Cataract has been the main reason of blinding in China. And the most preferred surgery of cataract is the cataract removing&intraocular lens implanting. During the implantation of IOL through surgery, the blood-aqueous humor barrier was broken. Protein and cell flood into the aqueous humor and could easily adsorb to the IOL surface, which may cause the inflamation and foreign body reaction. Also posterior capsule opacification can be caused by the migration and fibrosis of LECs in long-term. Therefore, the biocompatibility of IOL should comprise uveal biocompatibility and capsular biocompatibility. The uveal biocompatibility and capsular biocompatibility of IOL have close relationship with protein adsorption and cell adhension. In order to reduce the inflamation after implantation surgery and lower the chance of anterior capsule opacification, the anterior surface of intraocular lens should have the ability to resist protein adsorption and cell adhension.In this paper,2-(methacryloyloxy)ethyl2-(trimethylammonio)ethyl phosphate with great biocompatibiliy was co-polymerized with a-methacrylic acid by free radical solution polymerization process. The molecular weight could be modified by controlling the reaction time and the initiator/solvent.Plasma treatment under ammonia gas was used to modify the IOL surface and after that, the co-polymer P(MPC-co-MAA) was grafted onto the surface by amidation reaction. XPS spectra showed that there were peaks from the amido bond in the Cls and Nls peaks, which indicated that the co-polymer had been grafted onto the IOL successfully. Static contact angle, solid surface zeta-potential and QCM-D showed that after grafted onto the surface, the wettability increased significantly, the surface was negatively charged and the co-polymer on the surface still could keep the comformation. Also the BSA deposited onto the grafted surface can be washed off easily by PBS rinsing. The in-vitro cell experiment indicated that after modification, the IOL surface can resist LECs adhension without affecting LECs proliferation. The in-vivo experiment via rabbit eyes showed that the modified IOL can reduce the possibility of anterior capsule opacification...