Preparation And Application Of Crosslinked Microspheres Of Poly(Maleic Anhydride-alkyl Vinyl Ether-divinylbenzene)

Monodisperse polymer microspheres as a new class of polymer materials are used as theHPLC column filler, as carrier of drugs and the catalyst, and in preparation of biological orchemical sensor, and easy film-forming aqueous coating, because of its particle size uniformityand special physical and chemical properties, such as the large specific surface area, strongadsorption, low viscosity and high mobility. Therefore, monodisperse polymer microsphereshave become the hotspot of research and development of the domestic and foreign scholars, andhave a wide range of application prospects in many areas. Especially in recent years, theintroduction of various functional groups in the monodisperse polymer microspheres, make thisfunctional microspheres shows a good prospect in many high-tech fields such as bioengineering,immunoassay, electronic and microelectronic technology, information industry and highperformance liquid chromatography.Polymer microspheres is a new functional polymer materials and its chemical compositionand surface properties determine the key of the application. Because anhydride group has astrong polarity and a high reactivity, the subject selects maleic anhydride(MA) as a functionalmonomer. Maleic anhydride is difficult homopolymerize due to the steric effect, however as astrong electron-withdrawing monomer it can react with a variety of feeding monomers to forma charge transfer complex(CTC) which occurred in the alternating copolymerizationreaction.This issue prepared polymer microspheres containing functional groups through theprecipitation of the functional monomer with a crosslinking agent.In this paper, we prepared the two kinds of polymer microspheres containing theanhydride group, in MEK/Hp by precipitation polymerization with the maleic anhydride(MA),divinylbenzene(DVB), alkyl vinyl ether(AVE) monomers and AIBN as initiator,(1) Binaryhighly crosslinking microspheres P(MA-DVB),(2) the ternary low crosslinking microsphereP(MA-AVE-DVB). Their structures were characterized by FT-IR method.We studied the influence of the monomer ratio to the surface morphology of the two kindsof microspheres.The results show that, in order to form uniform microspheres with a smoothsurface,the molar content of DVB must be more than60%in P(MA-DVB). But inP(MA-AVE-DVB), the DVB moles content can be as low as10%due to introducing alkyl vinyl ether.We studied the particle size and particle size distribution of two different microspherescontaining anhydride group which composed of different monomer ratio.The results show that,the particle size is increasing with increasing molar content of DVB in binary microspheresP(MA-DVB) and the maximum polymer yield is up to96.30%when MA/DVB=4/6. Particlesize of the ternary microspheres P(MA-AVE-DVB) is also in line with this law and themaximum polymer yield is up to97.40%when MA/CHVE/DVB=4/4/2. The surface of theternary microspheres is smooth and the particle diameter close to the micron level.We studied anhydride content of two different microspheres containing anhydride groupwhich composed of different monomer ratio. The results show that, MA content in thepolymeric microspheres is gradually increased with the increase of the proportion of the MA inthe monomer mixture and the anhydride content in P(MA-AVE-DVB) was significantly higherthan the same MA feed ratio of MA/DVB binary microspheres. When added the third monomer,we found that an alkyl vinyl ether significantly reduces the degree of crosslinking of themicrospheres and improves the anhydride content of the microspheres.We can achieve quinoline-type chelating resina by reaction of ternary microspheres whichMA/CHVE/DVB is4/4/2with8-hydroxyquinoline. The results show that, in this esterificationreaction,8-hydroxyquinoline and ternary microspheres optimal feed ratio was1.2, the reactiontemperature was7h, the temperature was40°C, the ternary microspheres substrateconcentration was37.5mg/mL, and8-the hydroxyquinoline conversion rate can reach70%.we studied chelating resin adsorption ability of metal ions, the results show that,(1)theternary chelating resin has a strong chelate adsorption capacity for metal ions, and the ionadsorption capacity of Cu(II) reached6.93g/100g which is obviously higher than the binarychelating resin adsorption of Cu(II) ions.(2)the ternary chelating resin adsorption of Cu(II) ionswithin2h can achieve balance which showed rapid adsorption rate.(3) the adsorption processof the ternary chelating resin for the Cu(II) ions is the entropy driven chemical adsorption andtemperature is beneficial adsorption process.