Study On The Synthesis Of Benzo[G]Imidazo[1,2-α]Quinolinediones Derivatives And Organic Boron Compounds

The benzo[g]imidazo[1,2-a]quinolinediones skeleton is ubiquitous in a wide variety of naturally occurring and synthetic compounds that exhibit important biological activities including antibacterial, antiviral, cytotoxic, Aurora-B kinase inhibitory activities and anticancer activities against several cell lines. Hence, the synthesis of the benzo[g]imidazo[1,2-a]quinolinediones could be a valuable strategy to discover new bioactive compounds, but nowadays still have not effective methods to synthesize these compounds, in this paper we report an facil, rapid, effective, economy and ecologically method to synthesize these important compounds.The solvent-free reaction (SFR) is an important synthetic procedure from the viewpoint of green and sustainable chemistry. These approaches can help to reduce the amounts of undesired hazardous chemicals used, increase the selectivity towards the given products, and also enhance the rate of many organic reactions.Multicomponent reactions (MCR) are important strategy in drug discovery, especially in the synthesis of hetero-cyclic scaffolds, as well as in the total synthesis of natural products, which allows the generation of high levels of diversity giving rise to complex structures by the simultaneous formation of two or more bonds from simple substrates and provide unmatched opportunities for the expeditious increase in complexity of synthetic outcomesβ-Oxodithioesters heterocyclic ketene aminals (HKAs), have proven to be fascinating and versatile synthons in the construction of heterocyclic systems. Reactions of cyclic ketene aminals with a variety of biselectrophilic groups have so far been applied to make five-and six-membered, and fused heterocycles during the past years.In this paper, we have successfully developed a novel and economical, environmentally friendly one-pot three-component reaction to synthesize novel functionalized benzo[g]imidazo[1,2-a]quinolinediones via Et3N-assisted annulations under solvent-free conditions, which is the first report of preparation of title compounds by use of HKAs, aldehydes, and2-hydroxynaphthalene-1,4-dione.Boron and nitrogen, oxygen complexes is an important derivatives of the organoboron complexes, We use thioamide and BF3OEt2to synthesize N-O-B complexes, this might be resulted in the build-up of novel heterocyclic libraries of BF2complexes which could be potential valuable for pharmaceutical, agrochemical and organic metal materials applications.