The Preparation Of Carbon Doped With Graphene Screen-printing Electrode Array And Its Application

Graphene is a kind of two-dimensional carbon material, and has good conductivity, large surface area and good biocompatibility. Graphene has high electrocatalysis performance to some specific electricity and the substance, has been widely used in electrochemical analysis research. The application of graphene has been reported in the field of electrochemical analysis. In recent years, graphene was modified on the electrode surface mainly by coating, adsorption, embedment and covalent bond. Those motheds have some disadvantages. For example, graphene modified the electrode surface has poor stability and when modifing graphene to the small electrode array, the cross interference will produce. So, it has important significance to research a simple, convenient and firmly method of graphene modified electrode array in electrochemical field.The aim of the present work is to establish a simple and inexpensive fabrication method of carbon doped with graphene electrode array by screen printing method, and to establish the electrochemical analysis method for the simultaneous detection of multiple drugs small molecules. Research work in this thesis is financially supported by the National Natural Science Foundation of China (Grant No.21005003). This thesis includes three chapters.Chapter1is general introduction. In this chapter, the preparation methods of graphene were extensively described. The recent development of grapheme in electrochemical field was mainly reviewed. The recent development of screen-printing electrode array is simply introduced. Additionally, the purpose and main content of this research work were simply presented.Chapter2is preparation of graphite oxide and graphene. Graphite oxide was synthesized by the Hummers and modified Hummers method using flake graphite. Chemical composition, crystalline structure and oxidation degree of graphite oxide was studied by XRD, FT-IR, UV-vis and Raman spectroscopy to find a effective ways for preparation of graphite oxide. Graphene was prepared by chemical and electrochemical reduction method using graphite oxide obtained by modified Hummers method. The chemical composition, crystalline structure and morphology of graphene were studied by all kinds of methods. The electrochemical properties of graphene were researthed by electrochemical technology. It can be obtained that graphene using chemical and electrochemical reduction method obtained has good electrochemical properties, and can simultaneous detection of multiple drugs small molecules. But the process of prepatation for graphene using chemical reduction method obtained is complicated and time-consuming. Morever, graphene has bigger particle. Graphene of electrochemical reduction method obtained has a simple preparaed method, and aggregation problem was solved. But, the output of graphene is little.Chapter3is carbon doped with graphene screen-printing electrode array was fabractied by mixed graphene with carbon paste in3.3%proportion using mask technique and screen-printing technique. The proportion of graphene and the electrochemical properties of carbon doped with graphene screen-printing electrode array was studied by electrochemical technology. A good electrochemical analysis method was established for the simultaneous detection of drugs small molecules, such as, AA, UA and DA, hydroquinone, catechol and resorcinol, using carbon doped with graphene screen-printing electrode array fabracated. The work demonstrates that the selectivity of electrochemical method for isomers of dihydroxybenzenes is improved at the carbon doped with graphene screen-printing electrode array. The method will potentially be applied to multicomponent analysis in environmental control, the chemical industry and pharmaceutical detection.