Investigation Of Relay Recognition Fluorescent Probes Based On Quinoline Derivatives

Recent years scientists have focused on the study of the molecular level,understand the property and constitution of the structure via the intermoleculerinteractions (hydrogen bond, electrostatic force, van der Waals force, etc.), recognizingmacroscopic properties of chemical sensing from the microscopic scale. Since1987supramolecular concepts have been proposed, rapid development of the discipline playsa great role in the field of new materials, new energy, environmental reconnaissance andpollution prevention and control. This paper introduced the basic principles ofmolecular recognition, design and synthesis of three types of fluorescent probes, andinvestigated their spectral properties and the recognition mechanism. It contains fourparts:1、A brief introduction to the concept and mechanism of recognition about chemicalSensors, desired to design and develop a ligand having multiple functions.2、Relay recognition of Cu2+and CN by a new benzimidazole-containing quinazolinebased probe (1) has been achieved. Probe1exhibits highly selective and sensitivefluorescence “off-on” recognition properties to Cu2+in CH3CH2OH/H2O (1/1, v/v,HEPES20mM, pH=7.0) solution with a2:1binding stoichiometry. The in situ prepared1-Cu2+complex solution displays high selectivity to CN through fluorescence relayenhancement. This Cu2+and CN sequential recognition via fluorescence relayenhancement make probe1has a potential utility for Cu2+and CN detection in aqueousmedia.3、A click generated quinoline derivative has been synthesized and used as a fluorescentprobe for sequential recognition of Cu2+and pyrophosphate (PPi) in DMSO/H2O (1:1,v/v, HEPES20mM, pH=7.4) solution. Probe1displays high selectivity to Cu2+ions,and the in-situ prepared probe1-Cu2+exhibits high selectivity toward pyrophosphate (PPi) with emission recovery of probe1. Therefore,1-Cu2+complex can be applied as afluorescence turn-on probe for PPi with high selectivity and sensitivity.4、Two multifunctional probes based on quinoline derivative have been designed andsynthesized. The probes could rapid and sequentially recognize Cu2+and S2-in (1‰DMSO, HEPES20mM, pH=7.4) aqueous solution with high selectivity and sensitivity.