Study On One-Pot Synthesis Of4-Substituted1H-[1,2,3]Triazolo[4,5-c]Quinolines Through CuO-Promoted Tandem Cyclization Reactions

1,2,3-Triazoles derivatives represent an important class of organic compounds regarding their various biological and pharmacological properties. Therefore, they have wide applications in biological science, material chemistry, medicinal chemistry, and synthetic organic chemistry. Quinolines derivatives also are important biologically active motifs, and are ubiquitous in both natural products and active pharmaceutical ingredients (APIs). The main focus of this thesis has been on reviewing synthesis of1,2,3-triazoles and quinolines, and introducing our work on synthesis of4-substituted1H-[1,2,3]triazolo[4,5-c]quinolines. The thesis can be classified into three sections as follows:In the first chapter, the methods and development for the synthesis of1,2,3-triazoles were introduced. They can be classified into two kinds: coppercatalyzed Huisgen azide-alkyne cycloadditions (CuAAC), and the other synthetic methods.In the second chapter, the methods and development for the synthesis of quinolines were introduced. They can be classified into imino Diels-Alder reaction (Povarov reaction), the Friedlander reaction and the other synthetic methods.In the third chapter, a one-pot efficient copper-promoted tandem cyclization reaction to synthesize4-substituted-lH-[1,2,3]triazolo[4,5-c]quinolines was developed.