Preparation And Properties Of Capsaicin Delivery System

Capsaicin has many pharmacological functions, such as anti-inflammatory, analgesiceffect, anti-pruritus and antibacterial effect. It has been extensively studied in the field ofbiological medicine, agriculture, national defense and so on. But the disadvantages ofirritation, strong first-pass effect and short half-life limit its application. Therefore, we canstudy new Capsaicin delivery system to extend action time of the drug, reduce the irritation,and expand the application of Capsaicin.In order to diminish Capsaicin adverse drug reaction, we prepared Capsaicin deliverysystem. Firstly, because of the nano lamellar structure and good adsorption performance ofOMMT we prepared Capsaicin/OMMT intercalation composite, and the properties ofcomposite were studied. Secondly, another kind of thermal response type of shape memorypolyurethane had been chosen as drug carrier materials, which can control temperature easilyand have good biocompatibility, and the Capsaicin/SMPU composite had also been prepared.The drug controlled release effect and shape memory properties of composites wereinvestigated.The following results were obtained:The Capsaicin/OMMT composites with different drug-loaded amounts were successfullyprepared by solution intercalation method. The properties of composite were characterized byX-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and thermalgravimetric analysis (TGA). The results of XRD show that the layer space of OMMTincreased from1.9nm to3.7nm, which indicates Capsaicin insert into the OMMT interlayer.Moreover the thermal stability of Capsaicin was obviously improved by the intercalation, andthe decomposition temperature of the composite was improved to240℃. The time of the drugsustained release was48h by in vitro release test. The Capsaicin/OMMT composite has thedrug controlled release effect of Capsaicin.The Capsaicin/SMPU composite film with different drug-loaded amounts weresuccessfully prepared by the filling method (add the Capsaicin to Precursor-ASPU beforecross linked). The composite films were characterized by FTIR, TGA, DSC, DMA and SEM.The results show that the thermal stability of Capsaicin component of composites was obviously improved, and the decomposition temperature was improved to258℃whendrug-loaded amount was24wt%. The phase transition temperature of composite was37.6℃.The composite film had good shape memory behavior, the shape fixed ratio was99.4%andthe shape recovery ratio increased from93.1%to97.8%. The structure of Capsaicin/SMPUcomposite film becomes stable, shape recovery ratio improved obviously. The compositesalso show sustained release effect of Capsaicin and the time of the drug sustained release was24h by in vitro release test. Meanwhile, the results of SEM indicate that the surface of thecomposite film was dense structure. The composite not only keep great shape memoryproperty but also can control the release rate of the drug. It provides a method to the study ofCapsaicin slow delivery system.