Study On Immune Effector Cells In CALT Of Bactriancamels (Camelus Bactrianus)-IgA-secreting Cell, IgG-secreting Cell And FDC

Eye was the most impotant sense organ. It tended to be more influenced byoutside pathogenic microorganism because of contact with outside world directly.Conjunctiva-associated Lymphoid Tissue (CALT) not only provided protection andlocal immunity to eye but also participated in general immunity by Eyes droppingimmunity. In recent years, our group had done some basic study to it. In order to makefurther study to it, we took the gross anatomy, histology and immunohistochemistrymethods to comparing study some important immune effector cells in it. This researchmainly consists of following several parts: using Rabbit Anti-Bactrian camel IgA andIgG to research IgA and IgG-secreting cell. In addition, we also did some study toFollicular dendritic cells (FDC) and some other immune-associated cells. The resultsshowed that there were a lot of IgA and IgG-secreting cells, and most of them werelocated in the effector site of CALT. However, most of FDCs were located ininduction site.(1) Most of plasma cells of IgA were located evenly throughout laminapropria which closed to the epithelium by large numbers and dispersed distribution.The deeper in tissue the less number of plasma cells of IgA it had. There were a smallnumber of them around gland, and none of them was found in lymphoid nodules.(2)The location of IgG-secreting cells was similar to IgA-secreting cells, but the numberwas less than IgA-secreting cells.(3) We found there were a large number of FDC inlight zone of germinal center in lymphoid nodules, especially in the lymphoid nodulesthat had dome area. Besides, some melanocytes were found in mucosal epithelial cellsespecially in follicle-associated epithelium (FAE) with big area. There were a little ofthem in interfollicular area. There were a large number of goblet cells in epithelium.Above all, there were a large number of IgA and IgG-secreting cells in CALT ofBactrian camel. These cells were the foundation of mucosal immune. We were thefirst one to study CALT of Bactrian camel, and this study could make up for the blankto some extent, especially it could offer theoretical basis to Eyes dropping immunity.