| Objective: To investigate the myocardial protection of HTK solution for the severe valvularheart disease operation.Methods:48patients with severe valvular heart disease were divided into HTK group（n=24）and4:1cold cardioplegia group（n=24）.Serum cTnI,CK-MB and BNP were measured at3different timepoints（before aorta clamping,30mins after aorta clamping and24hours afteroperation）.The levels of cardiac biomarkers were compared between two groups.The value ofLVEF and LVEDV were also measured using colorful Doppler ultrosongraphy before and afteroperation,and subsequently compared between two groups.The clinical parameters includingcardiopulmonary bypass time,aorta clamping time,auto-beating rate,inotropic drag （dopamine）dosage,duration of mechanical ventilation,the volume of pericardiac and mediastinal drainage,the amount of blood transfusion,length of ICU stay and hospital charges were documented andanalysed.Result: The concentration of cardiac biomarkers increased after aorta clamping and operation inboth two groups.The levels were significantly lower in HTK group compared with those in coldcardioplegia group（P <0.05）.The auto beating ratio and postoperative LVEF were significantlyhigher in HTK group compared with cold cardioplegia group（P <0.05）.Meanwhile,thedopamine dosage, ventilation time, ICU stay duration and postoperative cardiothoracic ratiowere significantly lower in HTK group compared with those in cold cardioplegia group（P <0.05）.Conclusion: HTK solution exhibits higher value of myocardial protection in severe valvularheart operation. |
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