| Objective:1.Our purpose is to investigate the clinical features of children with primary immune thrombocytopenia hospitalized in Children’s Hospital of Shanxi Province from September2011to August2012.2.By observing the changes in the peripheral blood of children of primary immune thrombocytopenia platelet-associated antibodies and lymphocyte subsets to explore its relationship with primary immune thrombocytopenia and clinical significance.Methods:1.102cases that were treated with primary immune thrombocytopenia,from September2011to August2012the Department of Hematology, in Children’s Hospital of Shanxi Province,were for the study.2.Onset hospital diagnosed with primary immune thrombocytopenia in children with outpatient follow-up registration, in accordance with the latest international classification [1] into89cases as the observation group newly diagnosed ITP group (within3months after the diagnosis platelet continued to decline)66cases, persistent ITP group (3-12months after the diagnosis of platelet continued to decline),23cases over the same period to choose healthy children as a control group of25healthy subjects outpatient.3using SPSS17.0Version of statistical software for statistical analysis, the groups observed indicators are non-normal distribution, the measurement data with the median (inter-quartile range) that is (QR). The groups were compared using non-parametric tests rank transform analysis LSD test, alpha=0.05as significance level.Results:1Features:102patients in60males and42females, male/female ratio of1.43:1. Aged2months-14years old, and the median age was4.17years.-5Month of March, the length of stay of up to32cases, the December-January, followed by29cases,23cases of the Month of June-September,18cases-11months. All children with skin and (or) the mucosa of varying sizes bleeding and (or) ecchymosis, epistaxis21cases, bleeding gums or blood bud13cases, pulmonary hemorrhage cases, blood in the stool in3cases, incidence1-4weeks before infection,69cases,26cases of vaccination history.2.Compared with the normal control group, newly diagnosed ITP patients with persistent the ITP group of PAIg (G, M) levels were significantly higher than that in the control group, the difference was statistically significant (P<0.05); newly diagnosed ITP patients with persistent ITP group phaseratio, the level of platelet antibodies difference was not statistically significant (P>0.05); new diagnostic ITP group with persistent ITP group and control group, CD3+T cells, CD4+/CD8+T-cell ratio, CD3-CD (16+56)+NK cells reduced the percentage of CD3+CD8+T cells, CD19+B cells increased, the differences were statistically significant (P<0.05); newly diagnosed ITP patients with persistent ITP group, group CD3+T cells, CD3+CD4+T cells, CD4+/CD8+T-cell ratio, CD19+T cells, CD3+CD8+T-cell differences were statistically significant (P<0.05), CD3-CD (16+56)+NK cells was no significant difference (P>0.05).Conclusions:1.102cases initially diagnosed as children with primary immune thrombocytopenia have skin or mucosal bleeding, male/female ratio of1.43:1, age of onset is more concentrated in the3-6years of age (n=55)accounted for53.9%of the incidence of the month December-January (28.4%), March-May (31.4%), mostly in the month of September-11(17.6%) less.1-4weeks before the onset of infection accounted for67.6%, the vaccination history accounted for25.5%. Suggest that the disease no difference between men and women, more common in preschool children, winter and spring hair, may be associated with HIV infection and vaccination.2children with cellular and humoral immune disorders, provide a theoretical basis for clinical treatment. Platelet-associated antibodies available secondary diagnosis of primary ITP clinical prognostic significance in children is limited, and lymphocyte subsets platelet-associated antibody is superior in this regard, the joint use of both primary ITP diagnosis, response assessment of good practical value. |
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