The Study Of~1H-MRS And SWI In Parkinsons Disease

Objective: To investigate the metabolic changes in patients with Parkinson′s diseaseby MRS.Methods: All patients were recruited from the in-patient and out-patient of theAnqing petrol hospital，which were diagnosed primary Parkinson’s disease duringJune2010and May2012．There were28patients with PD(15men，13women)aged63.1±13.1，which had a mean disease duration of4.9±3.7年years，and18age-matched volunteers(11men and7women)as contml group，the mean age were62.2±12.4． All participants were informed consent． All patients were rated on theHoehn-Yahr scale，Hoehn-Yahr stage I～II15cases and Hoehn-Yahr stage III～Ⅳ13cases．The metabolite ratios of N-acetylasparatate(NAA)/creatine(Cr), andcholine-containing compounds(Cho)/Cr in PD patients were compared with those inthe age-matched healthy control subjects. Statistical analysis was performed by usingSPSS for Window(version19.0).Results:(1)No statistical difference between control group and PD ground werefound on conventional MR.(2) NAA/Cr ratios were reduced significantly(P<0.05)andCho/Cr ratios were increased significantly(P<0.05)in the head of caudate nucleus ofpatients with early-stage PD(Hoehn-Yahr stageⅠand II)and the both side of head ofcaudate nucleus of patients with middle and advanced PD(Hoehn-Yahr stage III andIV), compared to those in the age-matched healthy control subjects（.3）NAA，Cho，Cr and their ratios were not significant different in the ipsilateral and contralateralside of the putanen with severe symptoms in early PD and advanced PD group.Conclusion:（1）No statistical difference between PD group and control group werefound about conventional MRI.(2) Bilateral head of caudate nucleus by MRScontributes to diagnosis of PD, but it doesn’t contribute to the assessment of diseaseseverity in PD patients with bilateral limb symptoms. Objective: The study was to investigate the change of iron deposition in the brain ofPD patients noninvasively by using SWI phase value. To provide a noninvasive andvaluable biological indicator for the diagnosis of PD.Methods: All patients were recruited from the in-patient and out-patient of theAnqing petrol hospital，which were diagnosed primary Parkinson’s disease duringJune2010and May2012．There were33patients with PD(22men，11women)aged62.1±14.2，which had a mean disease duration of4.8±3.7years，and22age-matched volunteers(11men and11women)as control group，the mean age were62.2±12.4． All participants were informed consent． Conventional T1WI, T2WI,DWI, the SWI images were examined. The phase-shifted value of the bilateral headof caudate nucleus(CN), Putamen(PUT)，thalamus(TH),substantia nigra(SNr)，rednucleus(RN)，dentate mucleus(DN) and globus pallidus(GP) were evaluated in thecorrected phase image. Phase values were obtained from the formula as follows:f(x)=-x*π/4096.Statistical analysis was performed by using SPSS forWindow(version19.0).Results:(1)No statistical difference between control group and PD ground werefound on conventional MR.(2) The Phase value of bilateral CN、SNr and PUT in PDgroup were significantly higher than that in the control group.Conclusion: SWI provided a non-invasive methods for study the process ofpathological changes of iron deposition in PD and it can help us to recognize anddetect PD.