The Influence Of Compound Glycyrrhizin On The Nuclear Factor-κB,TNF-α And ICAM-1in Severe Acute Pancreatitis Patients

Objectives To explore the effect and the mechanism of compoundglycyrrhizin treatment for severe acute pancreatitis(SAP) by detectingtumor necrosis factor,nuclear transcription factor-κB and ICAM-1insevere acute pancreatitis patients with glycyrrhizin therapy.Methods80patients with SAP were randomly divided into SAPgroup(SAP group,n=40) and SAP glycyrrhizin treatment group(GLgroup,n=40).8cases underwent operation in SAP group,while6cases inGL group.Serum TNF-α and ICAM-1were detected by ELISA atadmission time and4days,7days after admission.NF-κBp65of pancreatictissue in all14cases who underwent operation were detected byimmunohistochemical technology.Results (1) The inhospital period of SAP group was longer than GLgroup (P<0.05). The levels of serum TNF-α and ICAM-1had nosignificant difference in SAP group and GL group at admissiontime,while the levels of serum TNF-α and ICAM-1in SAP group werehigherthan that in GL group4days,7days after admission (P<0.05).Theoperation and mortality rate in two groups were not significantdifferent(P>0.05). (2) NF-κBp65of pancreatic tissue in SAP group were stonger than thatin GL group (P<0.05).Conclusion:1. Compound Glycyrrhizin has some effect on SAPtreatment.2. Compound Glycyrrhizin may reduce inflammation in SAP patients byinhibition of NF-κ Bp65activity and the levels of serum TNF-α andICAM-1.