The Variance Of Basic Cor And ACTH In The Serum At The Early Stage Of RDS Premature Infant And Its Clinical Significance

Objective To search relationship between the variance and the occurrence of CLD,by investigating the variance of basic Cor and ACTH in the serum at the early stage ofRDS premature infant and the clinical stages of RDS.Methods We observed the47RDS premature infant in the NICU in the ChenzhouPeople’s First Hospital Affiliated to The South China University from July2011toApril2012. And in this paper, we took the32cases of healthy premature infant in thePremature Infant Unit and26cases of healthy term infant in the ObstetricalDepartment as control. All the venous blood samples were collected twice: one checkpoint is within24hours after delivery and the other check point is between8:00-9:00AM in the seventh day after delivery. The variance of Cor and ACTH in blood samplewere detected and calculated through chemiluminiscence way. The clinic stagesclassified into the mild (I-II grades) and moderately severe (III-IV grades) accordingthe initial chest radiography results. We compared and analysed between mild with orwithout CLD and the moderately severe groups.Results1The serum basic Cor data collected in the two check point comparison: the dataat the first check point of RDS premature infant is significantly higher than the one atthe second check point [(23.61±8.70)μg/dl VS (18.17±7.64)μg/dl, t=4.704, P=0.000],but the data variation of healthy premature infant and the healthy term infant isinsignificant (P>0.05).2The serum basic ACTH data collected in the two check point comparison: thedata at the first check point of RDS premature infant is significantly higher than theone at the second check point [(48.98±12.18)pg/ml VS (48.03±10.18)pg/ml, t=0.437, P=0.664], but the data variation of healthy premature infant and the healthy terminfant is insignificant (P>0.05).3The serum basic Cor levels for the three groups collected at the firstcheck-point is significant by ONE-WAY ANOVA (F=4.718, P=0.011). Then we havetaken LSD-t calculation method. The serum basic Cor of the RDS premature infant ishigher than the healthy premature infant at the first check-point (P <0.05) but the datavariation between the healthy premature infant and healthy term Infant is insignificant(P>0.05). The serum basic ACTH levels in the second check-point is significant byONE-WAY ANOVA (F=5.888, P=0.004). Then we have taken LSD-t calculationmethod. The date of the RDS premature infant is higher than that of the healthy infantgroups (P <0.05) but the difference between the healthy premature infant and that ofthe healthy term infant is insignificant (P>0.05).4The serum basic Cor levels collected at the second check-point is insignificantby ONE-WAY ANOVA (F=1.000, P=0.372). Then we have taken LSD-t calculationmethod. The serum basic ACTH in the RDS premature infant is higher than thehealthy premature infant at the second check-point (F=11.023, P=0.000). Then wehave taken LSD-t calculation method. The date of the RDS premature infant is higherthan that of the healthy premature infant and health term infant groups (P <0.05) butthe difference between the healthy premature infant and the healthy term infant isinsignificantly (P>0.05).5The variation of serum basic Cor and ACTH levels at those two check-pointbetween the mild and moderate serve groups is insignificant (P>0.05).6The variation of serum basic Cor and ACTH levels between CLD andnon-CLD groups at the two check-points, is insignificantly (P>0.05).Conclusion1The serum basic Cor of RDS premature infant is higher in that of the healthypremature infant and the healthy term infant but the serum basic Cor shows declinedcurve. The serum basic ACTH of RDS premature infant is higher than the healthypremature infant and healthy term infant at the two check-points prompt the early stage of RDS premature infant are under stress situation. Those babies have the Corsecretion and regulation functions. The serum basic Cor in the early stage of RDSpremature infant is correlation with the disease development.2The results of this study showed that the serum basic Cor and ACTH levels ofpremature infant with gestational age in30-34weeks suffered RDS can not be used asthe predictor to the clinical stages of RDS and CLD.