Research Of The Correlation Between Genital Tract Bacterial Infections And HPV Infection In Cervical Cancer

Objective: To study the vaginal flora distribution of cervical cancer patients andcommon pathogenic bacteria of antimicrobial resistance, then to detect whether vaginalbacteria infection can cooperated with HR-HPV infection increase the risk of cervical cancer.Methods:216new cervical cancer patients confirmed by pathology as the experimental group,and53cases chronic cervicitis eliminating other malignant tumor as the control. All thesufferers are from October2010to October2012in XinJiang Tumor Hospital. The twogroups before treatment in preliminary diagnosis are acquisition vaginal fluid for regularbacterial culture and HPV testing. To understand the distribution and drug resistance ofbacteria in two sets of vaginal secretions, and to analysis the bacterial infection with HPVinfection whether promote the occurrence of cervical cancer or not. Results:1.121cases ofcervical cancer patients with bacterial culture positive, positive rate of56%, gram-negativebacteria(74.38%), with high resistant rate of Ampicillin and Piperacillin; Gram positivebacteria(21.49%)which are resistant with penicillin and Erythromycin; Cervicitis patientsthere are26cases of bacterial culture positive, positive rate of49%, gram-negativebacteria(42.31%); Gram positive bacteria(23.08%). Stastic analysis revealed that there is nosignificant difference in the characteristics of pathogenic bacteria distribution and drugresistance between this two groups.2. The infection rate in cervical cancer is60.65%, whichis higher than cervicitis’41.51%, and results has statistical difference.3. The percentage ofpatient with HPV and bacteria concurrent infection is32.41%in cervical cancer, while22.64%in cervicitis(P>0.05). Conclusion: Cervical cancer patients changed vaginal flora,pathogenic bacteria especially escherichia coli is resisitant to traditional drug. While femalegenital tract bacterial infections as an HR-HPV infection risk factor is inadequate.